dc.creator | Muñoz-Delgado, Laura | es |
dc.creator | Macías-García, Daniel | es |
dc.creator | Periñán, María Teresa | es |
dc.creator | Jesús, Silvia | es |
dc.creator | Adarmes-Gómez, Astrid D. | es |
dc.creator | Bonilla Toribio, Marta | es |
dc.creator | García Díaz, Sergio | es |
dc.creator | Mir Rivera, Pablo | es |
dc.date.accessioned | 2023-04-19T12:57:05Z | |
dc.date.available | 2023-04-19T12:57:05Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Muñoz-Delgado, L., Macías-García, D., Periñán, M.T., Jesús, S., Adarmes-Gómez, A.D., Bonilla Toribio, M.,...,Mir Rivera, P. (2023). Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease. NPJ PARKINSONS DISEASE, 9 (1), 12. https://doi.org/10.1038/s41531-023-00457-5. | |
dc.identifier.issn | 2373-8057 | es |
dc.identifier.uri | https://hdl.handle.net/11441/144647 | |
dc.description.abstract | Peripheral inflammatory immune responses are thought to play a major role in the pathogenesis of Parkinson’s disease (PD). The
neutrophil-to-lymphocyte ratio (NLR), a biomarker of systemic inflammation, has been reported to be higher in patients with PD
than in healthy controls (HCs). The present study was aimed at determining if the peripheral inflammatory immune response could
be influenced by the genetic background of patients with PD. We included a discovery cohort with 222 patients with PD
(132 sporadic PD, 44 LRRK2-associated PD (with p.G2019S and p.R1441G variants), and 46 GBA-associated PD), as well as 299 HCs.
Demographic and clinical data were recorded. Leukocytes and their subpopulations, and the NLR were measured in peripheral
blood. Multivariate lineal regression and post-hoc tests were applied to determine the differences among the groups.
Subsequently, a replication study using the Parkinson’s Progression Markers Initiative cohort was performed which included 401
patients with PD (281 sPD patients, 66 LRRK2-PD patients, 54 GBA-PD patients) and a group of 174 HCs. Patients with sporadic PD
and GBA-associated PD showed a significantly lower lymphocyte count, a non-significantly higher neutrophil count and a
significantly higher NLR than HCs. The peripheral inflammatory immune response of patients with LRRK2-associated PD did not
differ from HCs. Our study supports the involvement of a peripheral inflammatory immune response in the pathophysiology of sPD
and GBA-associated PD. However, this inflammatory response was not found in LRRK2-associated PD, probably reflecting different
pathogenic inflammatory mechanisms. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer | es |
dc.relation.ispartof | NPJ PARKINSONS DISEASE, 9 (1), 12. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41531-023-00457-5 | es |
dc.identifier.doi | 10.1038/s41531-023-00457-5 | es |
dc.journaltitle | NPJ PARKINSONS DISEASE | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 12 | es |