dc.creator | Isla, Dolores | es |
dc.creator | Lopez-Brea, Marta | es |
dc.creator | Espinosa, María | es |
dc.creator | Arrabal, Natalia | es |
dc.creator | Pérez-Parente, Diego | es |
dc.creator | Carcedo, David | es |
dc.creator | Bernabé-Caro, Reyes | es |
dc.date.accessioned | 2023-04-18T12:57:02Z | |
dc.date.available | 2023-04-18T12:57:02Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Isla, D., Lopez-Brea, M., Espinosa, M., Arrabal, N., Pérez-Parente, D., Carcedo, D. y Bernabé-Caro, R. (2023). Cost-effectiveness of atezolizumab versus pembrolizumab as first-line treatment in PD-L1-positive advanced non-small-cell lung cancer in Spain. Cost Effectiveness and Resource Allocation, 21 (1), 6. https://doi.org/10.1186/s12962-023-00417-z. | |
dc.identifier.issn | 1478-7547 | es |
dc.identifier.uri | https://hdl.handle.net/11441/144585 | |
dc.description.abstract | Background Atezolizumab has recently been approved for first-line treatment of high PD-L1 expression metastatic
Non-Small-Cell Lung Cancer (NSCLC) patients with no EGFR or ALK mutations, on the basis of the IMpower110 trial.
This study aims to estimate the cost-effectiveness of atezolizumab compared with pembrolizumab among these
patients in Spanish settings, based on the results of the two cut-offs of the IMpower110 study.
Methods A three-state partitioned-survival model was adapted to Spanish settings to calculate health outcomes
and costs over a lifetime horizon. Clinical data for atezolizumab were collected from the interim and the exploratory
results (data cut-off: Sept’18 and Feb’20, respectively) of the IMpower110 trial while a network meta-analysis was used
to model pembrolizumab treatment. Utility data were collected from the trial. Direct medical costs were considered
based on resources identified by experts. Costs and outcomes were discounted at 3% per year. Health outcomes were
expressed as cost per Life Year (LY) and cost per Quality-Adjusted Life Year (QALY). Both deterministic and probabilistic
sensitivity analyses were performed to assess the robustness of results.
Results Over a lifetime horizon, the incremental results showed that atezolizumab generated similar health outcomes
(LYs and QALYs) to pembrolizumab, with minimal differences depending on the cut-off used (+ 0.70 and + 0.42
LYs and QALYs with Sept’18 cut-off and − 0.80 and − 0.72 LYs and QALYs with Feb’20 cut-off). However, for both
cut-offs, atezolizumab produced meaningfully less costs than pembrolizumab (€ − 54,261 with Sept’18 cut-off and €
− 81,907 with Feb’20 cut-off). The sensitivity analyses carried out confirmed the robustness of the base-case results.
Conclusions The cost-effectiveness analysis, comparing the two cut-off of IMpower110, shows that atezolizumab
provides similar health gains to pembrolizumab but at a lower cost for the first-line treatment of metastasic NSCLC
patients in Spain. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Cost Effectiveness and Resource Allocation, 21 (1), 6. | |
dc.rights | Attribution-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nd/4.0/ | * |
dc.subject | Atezolizumab | es |
dc.subject | Cost-effectiveness analysis | es |
dc.subject | IMpower110 trial | es |
dc.subject | Non-small cell lung cancer | es |
dc.subject | PD-L1 expression | es |
dc.subject | Pembrolizumab | es |
dc.title | Cost-effectiveness of atezolizumab versus pembrolizumab as first-line treatment in PD-L1-positive advanced non-small-cell lung cancer in Spain | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://resource-allocation.biomedcentral.com/articles/10.1186/s12962-023-00417-z | es |
dc.identifier.doi | 10.1186/s12962-023-00417-z | es |
dc.journaltitle | Cost Effectiveness and Resource Allocation | es |
dc.publication.volumen | 21 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 6 | es |