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Virological outcome among HiV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)
dc.creator | Beltrán-Pávez, Carolina | es |
dc.creator | Gutiérrez-López, Miguel | es |
dc.creator | Rubio-Garrido, Marina | es |
dc.creator | Valadés-Alcaraz, Ana | es |
dc.creator | Prieto, Luis | es |
dc.creator | Ramos, José Tomás | es |
dc.creator | López Cortés, Luis Fernando | es |
dc.date.accessioned | 2023-04-13T15:30:46Z | |
dc.date.available | 2023-04-13T15:30:46Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Beltrán-Pávez, C., Gutiérrez-López, M., Rubio-Garrido, M., Valadés-Alcaraz, A., Prieto, L., Ramos, J.T. y López Cortés, L.F. (2020). Virological outcome among HiV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017). Scientific Reports, 93 (6), 355-357. https://doi.org/10.1016/j.anpedi.2020.09.017. | |
dc.identifier.issn | 1695-4033 | es |
dc.identifier.issn | 1696-4608 | es |
dc.identifier.uri | https://hdl.handle.net/11441/144336 | |
dc.description.abstract | The aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid Cohort of HIV-infected children and adolescents in Spain. We included 106 non-transferred and 184 transferred patients under clinical follow-up in 17 public hospitals in Madrid by the end of December 2017. Virological and immunological outcomes were compared in transferred vs. non-transferred patients. ART drug resistance mutations and HIV-variants were analyzed in all subjects with available resistance pol genotypes and/or genotypic resistance profiles. Among the study cohort, 133 (72.3%) of 184 transferred and 75 (70.7%) of 106 non-transferred patients had available resistance genotypes. Most (88.9%) of transferred had ART experience at sampling. A third (33.3%) had had a triple-class experience. Acquired drug resistance (ADR) prevalence was significantly higher in pretreated transferred than non-transferred patients (71.8% vs. 44%; p = 0.0009), mainly to NRTI (72.8% vs. 31.1%; p < 0.0001) and PI (29.1% vs. 12%; p = 0.0262). HIV-1 non-B variants were less frequent in transferred vs. non-transferred (6.9% vs. 32%; p < 0.0001). In conclusion, the frequent resistant genotypes found in transferred youths justifies the reinforcement of HIV resistance monitoring after the transition to avoid future therapeutic failures. | es |
dc.description.sponsorship | Instituto de Salud Carlos III. España | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Scientific Reports, 93 (6), 355-357. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Virological outcome | es |
dc.subject | HIV | es |
dc.subject | Pediatric patient | es |
dc.subject | Adult units | es |
dc.subject | Spain | es |
dc.title | Virological outcome among HiV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017) | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla.Departamento de Medicina | es |
dc.relation.projectID | PI15/01005-RIS_EPICLIN-02/2016 | es |
dc.relation.publisherversion | http://doi.org/10.1016/j.anpedi.2020.09.017 | es |
dc.identifier.doi | 10.1016/j.anpedi.2020.09.017 | es |
dc.journaltitle | Scientific Reports | es |
dc.publication.volumen | 93 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 355 | es |
dc.publication.endPage | 357 | es |