Artículo
Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women. Influence of type 2 diabetes mellitus
Autor/es | Gómez de Tejada Romero, María Jesús
Saavedra-Santana, P. de la Rosa-Fernández, F. Suárez-Ramírez, N. Martín-Martínez, A. Sosa-Henríquez, M. |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2022-07-04 |
Fecha de depósito | 2023-04-11 |
Publicado en |
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Resumen | Aims To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal
women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them.
Methods 679 ... Aims To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them. Methods 679 postmenopausal women were grouped into obese and non-obese. Obese women were grouped into those with T2DM and those without. 25(OH)-vitamin D, PTH and BMD were measured, and prevalent fragility fractures were gathered. Results Obese women had higher prevalence of T2DM, than non-obese women. Levels of 25(OH)-vitamin D were lower and those of PTH higher in obese women, BMD values were higher in obese women. Diabetic-obese women had a higher prevalence of non-vertebral fractures than non-diabetic-obese. Multivariate logistic regression model showed association of fragility fractures with age, total hip BMD, BMI and T2DM. Obese women have higher BMD and lower 25(OH)-vitamin D values (and higher PTH) than non-obese, without diabetes. Conclusions T2DM confers an increased risk of non-vertebral fractures in postmenopausal obese women. |
Cita | Gómez de Tejada Romero, M.J., Saavedra-Santana, P., de la Rosa-Fernández, F., Suárez-Ramírez, N., Martín-Martínez, A. y Sosa-Henríquez, M. (2022). Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women. Influence of type 2 diabetes mellitus. Acta Diabetologica, 59 (9), 1201-1208. https://doi.org/10.1007/s00592-022-01923-x. |
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