dc.creator | Navarro, Francisco | es |
dc.creator | Toimil, Alberto | es |
dc.creator | Ramírez, Sara | es |
dc.creator | Montero, Yina | es |
dc.creator | Fuentes, Juan Luis | es |
dc.creator | Perona, Javier S. | es |
dc.creator | Castaño, Miguel Ángel | es |
dc.creator | Pásaro Dionisio, María Rosario | es |
dc.creator | Vega Piqueres, José María | es |
dc.creator | Vílchez, Carlos | es |
dc.date.accessioned | 2023-03-09T14:49:26Z | |
dc.date.available | 2023-03-09T14:49:26Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Navarro, F., Toimil, A., Ramírez, S., Montero, Y., Fuentes, J.L., Perona, J.S.,...,Vílchez, C. (2020). The Acidophilic Microalga Coccomyxa Onubensis and Atorvastatin Equally Improve Antihyperglycemic and Antihyperlipidemic Protective Effects on Rats Fed on High-fat Diets. Journal of Applied Phycology, 32 (6), 3923-3931. https://doi.org/10.1007/s10811-020-02280-4. | |
dc.identifier.issn | 0921-8971 | es |
dc.identifier.issn | 1573-5176 | es |
dc.identifier.uri | https://hdl.handle.net/11441/143255 | |
dc.description.abstract | Biomass of the acidophilic green alga Coccomyxa onubensis may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement of C. onubensis powder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both ω–3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however, C. onubensis powder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (ω–6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats. | es |
dc.description.sponsorship | Universidad de Huelva BIO–214 | es |
dc.format | application/pdf | es |
dc.format.extent | 23 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Journal of Applied Phycology, 32 (6), 3923-3931. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Atorvastatin | es |
dc.subject | Chlorophyceae | es |
dc.subject | Coccomyxa onubensis | es |
dc.subject | Hypercholesterolemia | es |
dc.subject | Hyperglycemia | es |
dc.subject | Polyunsaturated fatty acids | es |
dc.subject | Rat metabolic syndrome | es |
dc.title | The Acidophilic Microalga Coccomyxa Onubensis and Atorvastatin Equally Improve Antihyperglycemic and Antihyperlipidemic Protective Effects on Rats Fed on High-fat Diets | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.projectID | BIO–214 | es |
dc.relation.publisherversion | https://dx.doi.org/10.1007/s10811-020-02280-4 | es |
dc.identifier.doi | 10.1007/s10811-020-02280-4 | es |
dc.journaltitle | Journal of Applied Phycology | es |
dc.publication.volumen | 32 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 3923 | es |
dc.publication.endPage | 3931 | es |
dc.contributor.funder | Universidad de Huelva | es |