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Artículo
The Acidophilic Microalga Coccomyxa Onubensis and Atorvastatin Equally Improve Antihyperglycemic and Antihyperlipidemic Protective Effects on Rats Fed on High-fat Diets
Autor/es | Navarro, Francisco
Toimil, Alberto Ramírez, Sara Montero, Yina Fuentes, Juan Luis Perona, Javier S. Castaño, Miguel Ángel Pásaro Dionisio, María Rosario Vega Piqueres, José María Vílchez, Carlos |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Fecha de publicación | 2020 |
Fecha de depósito | 2023-03-09 |
Publicado en |
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Resumen | Biomass of the acidophilic green alga Coccomyxa onubensis may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic ... Biomass of the acidophilic green alga Coccomyxa onubensis may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement of C. onubensis powder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both ω–3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however, C. onubensis powder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (ω–6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats. |
Agencias financiadoras | Universidad de Huelva |
Identificador del proyecto | BIO–214 |
Cita | Navarro, F., Toimil, A., Ramírez, S., Montero, Y., Fuentes, J.L., Perona, J.S.,...,Vílchez, C. (2020). The Acidophilic Microalga Coccomyxa Onubensis and Atorvastatin Equally Improve Antihyperglycemic and Antihyperlipidemic Protective Effects on Rats Fed on High-fat Diets. Journal of Applied Phycology, 32 (6), 3923-3931. https://doi.org/10.1007/s10811-020-02280-4. |
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