dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | Bermúdez Pulgarín, Beatriz | es |
dc.creator | López Martín, Sergio | es |
dc.creator | Naranjo, Maria C. | es |
dc.creator | Romero, Yolanda | es |
dc.creator | Bando Hidalgo, María J. | es |
dc.creator | Abia González, María del Rocío | es |
dc.creator | Muriana, Francisco J. G. | es |
dc.date.accessioned | 2023-01-25T10:15:43Z | |
dc.date.available | 2023-01-25T10:15:43Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Montserrat de la Paz, S., Bermúdez Pulgarín, B., López Martín, S., Naranjo, M.C., Romero, Y., Bando Hidalgo, M.J.,...,Muriana, F.J.G. (2017). Exogenous fatty acids and niacin on acute prostaglandin D-2 production in human myeloid cells. Journal of Nutritional Biochemistry, 39, 22-31. https://doi.org/10.1016/j.jnutbio.2016.09.007. | |
dc.identifier.issn | 0955-2863 | es |
dc.identifier.issn | 1873-4847 | es |
dc.identifier.uri | https://hdl.handle.net/11441/141850 | |
dc.description.abstract | Niacin activates HCA2 receptor that results in the release of PGD2. However, little is known on PGD2-producing cells and the role of fatty acids. Notably M-CSF macrophages exhibited a timely dependent PGD2 production upon niacin challenge. Short pretreatment of M-CSF macrophages with autologous postprandial TRLs induced the down-regulation of HCA2 gene and up-regulation of genes encoding COX1 and COX2 enzymes in a fatty acid-dependent manner. These effects were paralleled by a higher PGD2 production with postprandial TRL-SFAs. The niacin-mediated transcriptional activity of all genes involved in PGD2 biosynthesis was desensitized in a time-dependent manner by postprandial TRLs, leading to a decreased PGD2 release. In vivo, the net excursions of PGD2 in plasma followed similar fatty acid-dependent patterns as those found for PGD2 release in vitro. The predominant fatty acid class in the diet acutely modulates PGD2 biosynthetic pathway both in vitro and in vivo. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación de España (MICINN)-AGL2011-29008 y BES-2012-056104 | es |
dc.description.sponsorship | Universidad de Sevilla-V Plan Propio de Investigación-VPPI-US | es |
dc.description.sponsorship | Consejo Superior de Investigaciones Científicas de España (CSIC)/Juan de la Cierva | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Journal of Nutritional Biochemistry, 39, 22-31. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Niacin | es |
dc.subject | Exogenous fatty acids | es |
dc.subject | Postprandial state | es |
dc.subject | Prostaglandin D2 | es |
dc.subject | Myeloid cells | es |
dc.title | Exogenous fatty acids and niacin on acute prostaglandin D-2 production in human myeloid cells | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.relation.projectID | AGL2011-29008 | es |
dc.relation.projectID | BES-2012-056104 | es |
dc.relation.projectID | VPPI-US | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.jnutbio.2016.09.007 | es |
dc.identifier.doi | 10.1016/j.jnutbio.2016.09.007 | es |
dc.journaltitle | Journal of Nutritional Biochemistry | es |
dc.publication.volumen | 39 | es |
dc.publication.initialPage | 22 | es |
dc.publication.endPage | 31 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | Universidad de Sevilla | es |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (CSIC) | es |