Article
Exogenous fatty acids and niacin on acute prostaglandin D-2 production in human myeloid cells
Author/s | Montserrat de la Paz, Sergio
Bermúdez Pulgarín, Beatriz López Martín, Sergio Naranjo, Maria C. Romero, Yolanda Bando Hidalgo, María J. Abia González, María del Rocío Muriana, Francisco J. G. |
Department | Universidad de Sevilla. Departamento de Biología Celular |
Publication Date | 2017 |
Deposit Date | 2023-01-25 |
Published in |
|
Abstract | Niacin activates HCA2 receptor that results in the release of PGD2. However, little is known on PGD2-producing cells and the role of fatty acids. Notably M-CSF macrophages exhibited a timely dependent PGD2 production upon ... Niacin activates HCA2 receptor that results in the release of PGD2. However, little is known on PGD2-producing cells and the role of fatty acids. Notably M-CSF macrophages exhibited a timely dependent PGD2 production upon niacin challenge. Short pretreatment of M-CSF macrophages with autologous postprandial TRLs induced the down-regulation of HCA2 gene and up-regulation of genes encoding COX1 and COX2 enzymes in a fatty acid-dependent manner. These effects were paralleled by a higher PGD2 production with postprandial TRL-SFAs. The niacin-mediated transcriptional activity of all genes involved in PGD2 biosynthesis was desensitized in a time-dependent manner by postprandial TRLs, leading to a decreased PGD2 release. In vivo, the net excursions of PGD2 in plasma followed similar fatty acid-dependent patterns as those found for PGD2 release in vitro. The predominant fatty acid class in the diet acutely modulates PGD2 biosynthetic pathway both in vitro and in vivo. |
Funding agencies | Ministerio de Ciencia, Innovación y Universidades (MICINN). España Universidad de Sevilla Consejo Superior de Investigaciones Científicas (CSIC) |
Project ID. | AGL2011-29008
BES-2012-056104 VPPI-US |
Citation | Montserrat de la Paz, S., Bermúdez Pulgarín, B., López Martín, S., Naranjo, M.C., Romero, Y., Bando Hidalgo, M.J.,...,Muriana, F.J.G. (2017). Exogenous fatty acids and niacin on acute prostaglandin D-2 production in human myeloid cells. Journal of Nutritional Biochemistry, 39, 22-31. https://doi.org/10.1016/j.jnutbio.2016.09.007. |
Files | Size | Format | View | Description |
---|---|---|---|---|
Postprint_2017_JNutBiochem_V39 ... | 548.8Kb | [PDF] | View/ | Versión aceptada del artículo publicado. |