dc.creator | Cano, Ángela | es |
dc.creator | Gutiérrez Gutiérrez, Belén | es |
dc.creator | Machuca, Isabel | es |
dc.creator | Torre-Giménez, Julián | es |
dc.creator | Gracia Ahufinger, Irene | es |
dc.creator | Natera, Alejandra M. | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.creator | Torre-Cisneros, Julián | es |
dc.date.accessioned | 2022-12-20T18:29:38Z | |
dc.date.available | 2022-12-20T18:29:38Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Cano, Á., Gutiérrez Gutiérrez, B., Machuca, I., Torre-Giménez, J., Gracia Ahufinger, I., Natera, A.M.,...,Torre-Cisneros, J. (2022). Association between Timing of Colonization and Risk of Developing Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Infection in Hospitalized Patients. Microbiology Spectrum, 10 (2), e0197021. https://doi.org/10.1128/spectrum.01970-21. | |
dc.identifier.issn | 2165-0497 | es |
dc.identifier.uri | https://hdl.handle.net/11441/140696 | |
dc.description.abstract | Colonization by KPC-producing Klebsiella pneumoniae (KPC-Kp) is associ ated with the risk of developing KPC-Kp infection. The impact of the time elapsed since
a patient becomes colonized on this risk is not well known. An observational, prospec tive, longitudinal cohort study of colonized patients undergoing active rectal culture
screening to rule out KPC-Kp colonization (July 2012 to November 2017). Patients with
a positive culture at inclusion (colonized at start of follow-up) and those with a negative
culture at inclusion who became colonized within 90 days (colonized during follow-up)
were included in the analysis. CART analysis was used to dichotomize variables accord ing to their association with infection. Kaplan–Meier infection-free survival curves and
the log-rank test were used for group comparisons. Logistic regression was used to
identify variables associated with KPC-Kp infection. Among 1310 patients included, 166
were colonized at the end of follow-up. Forty-seven out of 118 patients colonized at
start of follow-up developed infection (39.8%) versus 31 out of 48 patients colonized
during follow-up (64.6%; P = 0.006). Variables associated with KPC-Kp infection in the
logistic regression analysis were: colonization detection during follow-up (OR, 2.74; 95%
CI, 1.07 to 7.04; P = 0.03), Giannella risk score (OR, 1.51; 95% CI, 1.32 to 1.73; P ,
0.001), high-risk ward (OR, 4.77; 95% CI, 1.61 to 14.10; P = 0.005) and urological manipu lation after admission (OR, 3.69; 95% CI, 1.08 to 12.60; P = 0.04). In 25 out of 31 patients
(80.6%) colonized during follow-up who developed KPC-Kp infection, infection appeared
within 15 days after colonization. The risk of KPC-Kp infection was higher when coloni zation is recently acquired during hospitalization. In this prospective study, we con cluded that the timing of colonization was a factor to assess when considering empiri cal treatment for suspected KPC-Kp infection and prophylaxis or infection control. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | AMER SOC MICROBIOLOGY | es |
dc.relation.ispartof | Microbiology Spectrum, 10 (2), e0197021. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Carbapenemase-producing Klebsiella pneumoniae | es |
dc.subject | Timing of colonization | es |
dc.subject | Risk of infection | es |
dc.title | Association between Timing of Colonization and Risk of Developing Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Infection in Hospitalized Patients | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://journals.asm.org/doi/10.1128/spectrum.01970-21 | es |
dc.identifier.doi | 10.1128/spectrum.01970-21 | es |
dc.journaltitle | Microbiology Spectrum | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | e0197021 | es |