Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma

Ohmura, Shunya; Marchetto, Aruna; Orth, Martin F.; Li, Jing; Jabar, Susanne; Ranft, Andreas; Romero Pérez, Laura; Grünewald, Thomas G. P.

doi:10.1186/s12943-021-01393-9

Artículo

dc.creator	Ohmura, Shunya	es
dc.creator	Marchetto, Aruna	es
dc.creator	Orth, Martin F.	es
dc.creator	Li, Jing	es
dc.creator	Jabar, Susanne	es
dc.creator	Ranft, Andreas	es
dc.creator	Romero Pérez, Laura	es
dc.creator	Grünewald, Thomas G. P.	es
dc.date.accessioned	2022-12-20T16:48:45Z
dc.date.available	2022-12-20T16:48:45Z
dc.date.issued	2021-07-27
dc.identifier.citation	Ohmura, S., Marchetto, A., Orth, M.F., Li, J., Jabar, S., Ranft, A.,...,Grünewald, T.G.P. (2021). Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma. Molecular Cancer, 20 (1), 97. https://doi.org/10.1186/s12943-021-01393-9.
dc.identifier.issn	1476-4598	es
dc.identifier.uri	https://hdl.handle.net/11441/140688
dc.description.abstract	Ewing sarcoma (EwS) is an aggressive bone- or soft tissue-associated malignancy, characterised by the fusion oncoprotein EWSR1-FLI1 [1]. Over the past decades further therapeutic development for this devastating childhood tumour has remained relatively stagnant [2], especially for patients with metastatic or recurrent disease [3, 4]. To develop more effective and specific treatment options we investigated potential therapeutic targets by exploring putative downstream genes of EWSR1-FLI1. (extracted from the main text)	es
dc.format	application/pdf	es
dc.format.extent	7 p.	es
dc.language.iso	eng	es
dc.publisher	BMC	es
dc.relation.ispartof	Molecular Cancer, 20 (1), 97.
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Ewing sarcoma	es
dc.subject	RRM2	es
dc.subject	Targeted therapy	es
dc.subject	Prognostic biomarker	es
dc.subject	Paediatric oncology	es
dc.subject	Triapine	es
dc.subject	Chemoresistance	es
dc.title	Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma	es
dc.type	info:eu-repo/semantics/article	es
dcterms.identifier	https://ror.org/03yxnpp24
dc.type.version	info:eu-repo/semantics/publishedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica	es
dc.relation.publisherversion	https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-021-01393-9	es
dc.identifier.doi	10.1186/s12943-021-01393-9	es
dc.journaltitle	Molecular Cancer	es
dc.publication.volumen	20	es
dc.publication.issue	1	es
dc.publication.initialPage	97	es

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