dc.creator | Ohmura, Shunya | es |
dc.creator | Marchetto, Aruna | es |
dc.creator | Orth, Martin F. | es |
dc.creator | Li, Jing | es |
dc.creator | Jabar, Susanne | es |
dc.creator | Ranft, Andreas | es |
dc.creator | Romero Pérez, Laura | es |
dc.creator | Grünewald, Thomas G. P. | es |
dc.date.accessioned | 2022-12-20T16:48:45Z | |
dc.date.available | 2022-12-20T16:48:45Z | |
dc.date.issued | 2021-07-27 | |
dc.identifier.citation | Ohmura, S., Marchetto, A., Orth, M.F., Li, J., Jabar, S., Ranft, A.,...,Grünewald, T.G.P. (2021). Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma. Molecular Cancer, 20 (1), 97. https://doi.org/10.1186/s12943-021-01393-9. | |
dc.identifier.issn | 1476-4598 | es |
dc.identifier.uri | https://hdl.handle.net/11441/140688 | |
dc.description.abstract | Ewing sarcoma (EwS) is an aggressive bone- or soft tissue-associated malignancy, characterised by the fusion oncoprotein EWSR1-FLI1 [1]. Over the past decades further therapeutic development for this devastating childhood tumour has remained relatively stagnant [2], especially for patients with metastatic or recurrent disease [3, 4]. To develop more effective and specific treatment options we investigated potential therapeutic targets by exploring putative downstream genes of EWSR1-FLI1.
(extracted from the main text) | es |
dc.format | application/pdf | es |
dc.format.extent | 7 p. | es |
dc.language.iso | eng | es |
dc.publisher | BMC | es |
dc.relation.ispartof | Molecular Cancer, 20 (1), 97. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Ewing sarcoma | es |
dc.subject | RRM2 | es |
dc.subject | Targeted therapy | es |
dc.subject | Prognostic biomarker | es |
dc.subject | Paediatric oncology | es |
dc.subject | Triapine | es |
dc.subject | Chemoresistance | es |
dc.title | Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.relation.publisherversion | https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-021-01393-9 | es |
dc.identifier.doi | 10.1186/s12943-021-01393-9 | es |
dc.journaltitle | Molecular Cancer | es |
dc.publication.volumen | 20 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 97 | es |