Article
Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma
Author/s | Ohmura, Shunya
Marchetto, Aruna Orth, Martin F. Li, Jing Jabar, Susanne Ranft, Andreas Romero Pérez, Laura Grünewald, Thomas G. P. |
Department | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica |
Publication Date | 2021-07-27 |
Deposit Date | 2022-12-20 |
Published in |
|
Abstract | Ewing sarcoma (EwS) is an aggressive bone- or soft tissue-associated malignancy, characterised by the fusion oncoprotein EWSR1-FLI1 [1]. Over the past decades further therapeutic development for this devastating childhood ... Ewing sarcoma (EwS) is an aggressive bone- or soft tissue-associated malignancy, characterised by the fusion oncoprotein EWSR1-FLI1 [1]. Over the past decades further therapeutic development for this devastating childhood tumour has remained relatively stagnant [2], especially for patients with metastatic or recurrent disease [3, 4]. To develop more effective and specific treatment options we investigated potential therapeutic targets by exploring putative downstream genes of EWSR1-FLI1. (extracted from the main text) |
Citation | Ohmura, S., Marchetto, A., Orth, M.F., Li, J., Jabar, S., Ranft, A.,...,Grünewald, T.G.P. (2021). Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma. Molecular Cancer, 20 (1), 97. https://doi.org/10.1186/s12943-021-01393-9. |
Files | Size | Format | View | Description |
---|---|---|---|---|
Translational evidence for RRM2 ... | 2.256Mb | [PDF] | View/ | |