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dc.creatorCorma-Gómez, Aes
dc.creatorMacías Sánchez, Juanes
dc.creatorRivero, A.es
dc.creatorRivero-Juárez, A.es
dc.creatorSantos, I. de loses
dc.creatorReus-Bañuls, S.es
dc.creatorGonzález-Serna Martín, Manuel Alejandroes
dc.creatorPineda Vergara, Juan Antonioes
dc.date.accessioned2022-12-09T16:44:57Z
dc.date.available2022-12-09T16:44:57Z
dc.date.issued2021-08-20
dc.identifier.citationCorma-Gómez, A., Macías Sánchez, J., Rivero, A., Rivero-Juárez, A., Santos, I.d.l., Reus-Bañuls, S.,...,Pineda Vergara, J.A. (2021). A genome-wide association study on liver stiffness changes during hepatitis c virus infection cure. Diagnostics, 11, 8-1501. https://doi.org/10.3390/diagnostics11081501.
dc.identifier.issn2075-4418es
dc.identifier.urihttps://hdl.handle.net/11441/140285
dc.description.abstractLiver stiffness (LS) at sustained virological response (SVR) after direct-acting antivirals (DAA)-based therapy is a predictor of liver events in hepatitis C virus (HCV)-infected patients. The study aim was to identify genetic factors associated with LS changes from the moment of starting anti-HCV therapy to SVR. This prospective study included HCV-infected patients from the GEHEP 011 cohort who achieved SVR with DAA-based therapy, with LS pre-treatment ≥9.5 kPa and LS measurement available at SVR. Plink and Magma software were used to carry out genome-wide single-nucleotide polymorphism (SNP)-based and gene-based association analyses, respectively. The ShinyGO application was used for exploring enrichment in Gene Ontology (GO) categories for biological processes. Overall, 242 patients were included. Median (quartile 1, quartile 3) LS values at pre-treatment and at SVR were 16.8 (12, 28) kPa and 12.0 (8.5, 19.3) kPa, respectively. Thirty-five SNPs and three genes reached suggestive association with LS changes from the moment of starting anti HCV therapy to SVR. GO categories related to DNA packaging complex, DNA conformation change, chromosome organization and chromatin organization were significantly enriched. Our study reports possible genetic factors associated with LS changes during HCV-infection cure. In addition, our results suggest that processes related to DNA conformation are also involved in these changes.es
dc.formatapplication/pdfes
dc.format.extent11 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofDiagnostics, 11, 8-1501.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGWASes
dc.subjectHepatitis C virus infectiones
dc.subjectPolymorphismses
dc.subjectSustained virological responsees
dc.subjectDirect-acting antiviralses
dc.subjectLiver stiffnesses
dc.titleA genome-wide association study on liver stiffness changes during hepatitis c virus infection curees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiologíaes
dc.relation.projectIDPI-0001/2017es
dc.relation.projectIDPI16/01443es
dc.relation.projectIDPI19/01312es
dc.relation.publisherversionhttps://www.mdpi.com/2075-4418/11/8/1501es
dc.identifier.doi10.3390/diagnostics11081501es
dc.journaltitleDiagnosticses
dc.publication.issue11es
dc.publication.initialPage8es
dc.publication.endPage1501es
dc.contributor.funderConsejería de Salud Junta de Andalucíaes
dc.contributor.funderInstituto de Salud Carlos IIIes

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Except where otherwise noted, this item's license is described as: Atribución 4.0 Internacional