dc.creator | Jimenez, David | es |
dc.creator | Agusti, Alvar | es |
dc.creator | Tabernero, Eva | es |
dc.creator | Jara-Palomares, Luis | es |
dc.creator | Hernando, Ascension | es |
dc.creator | Ruiz-Artacho, Pedro | es |
dc.creator | Otero Candelera, Remedios | es |
dc.date.accessioned | 2022-12-07T15:40:08Z | |
dc.date.available | 2022-12-07T15:40:08Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Jimenez, D., Agusti, A., Tabernero, E., Jara-Palomares, L., Hernando, A., Ruiz-Artacho, P. y Otero Candelera, R. (2021). Effect of a Pulmonary Embolism Diagnostic Strategy on Clinical Outcomes in Patients Hospitalized for COPD Exacerbation A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 326 (13), 1277-1285. https://doi.org/10.1001/jama.2021.14846. | |
dc.identifier.issn | 0098-7484 | es |
dc.identifier.issn | 1538-3598 | es |
dc.identifier.uri | https://hdl.handle.net/11441/140218 | |
dc.description.abstract | OBJECTIVE To compare usual care plus an active strategy for diagnosing PE with usual care
alone in patients hospitalized for COPD exacerbation.
DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial conducted across 18 hospitals
in Spain. A total of 746 patients were randomized from September 2014 to July 2020
(final follow-up was November 2020).
INTERVENTIONS Usual care plus an active strategy for diagnosing PE (D-dimer testing and, if
positive, computed tomography pulmonary angiogram) (n = 370) vs usual care (n = 367).
MAIN OUTCOMES AND MEASURES The primary outcome was a composite of nonfatal
symptomatic venous thromboembolism (VTE), readmission for COPD, or death within 90
days after randomization. There were 4 secondary outcomes, including nonfatal new or
recurrent VTE, readmission for COPD, and death from any cause within 90 days. Adverse
events were also collected.
RESULTS Among the 746 patients who were randomized, 737 (98.8%) completed the trial
(mean age, 70 years; 195 [26%] women). The primary outcome occurred in 110 patients
(29.7%) in the intervention group and 107 patients (29.2%) in the control group (absolute risk
difference, 0.5% [95% CI, −6.2% to 7.3%]; relative risk, 1.02 [95% CI, 0.82-1.28]; P = .86).
Nonfatal new or recurrent VTE was not significantly different in the 2 groups (0.5% vs 2.5%;
risk difference, −2.0% [95% CI, −4.3% to 0.1%]). By day 90, a total of 94 patients (25.4%) in
the intervention group and 84 (22.9%) in the control group had been readmitted for
exacerbation of COPD (risk difference, 2.5% [95% CI, −3.9% to 8.9%]). Death from any cause
occurred in 23 patients (6.2%) in the intervention group and 29 (7.9%) in the control group
(risk difference, −1.7% [95% CI, −5.7% to 2.3%]). Major bleeding occurred in 3 patients
(0.8%) in the intervention group and 3 patients (0.8%) in the control group (risk difference,
0% [95% CI, −1.9% to 1.8%]; P = .99).
CONCLUSIONS AND RELEVANCE Among patients hospitalized for an exacerbation of COPD, the
addition of an active strategy for the diagnosis of PE to usual care, compared with usual care
alone, did not significantly improve a composite health outcome. The study may not have had
adequate power to assess individual components of the composite outcome.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT02238639 | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | AMER MEDICAL ASSOCIATION | es |
dc.relation.ispartof | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 326 (13), 1277-1285. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Pulmonary Embolism | es |
dc.subject | Diagnostic Strategy | es |
dc.subject | Patients Hospitalized | es |
dc.subject | COPD Exacerbation | es |
dc.title | Effect of a Pulmonary Embolism Diagnostic Strategy on Clinical Outcomes in Patients Hospitalized for COPD Exacerbation A Randomized Clinical Trial | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | PI14/ 00400 | es |
dc.relation.publisherversion | https://jamanetwork.com/journals/jama/fullarticle/2784660 | es |
dc.identifier.doi | 10.1001/jama.2021.14846 | es |
dc.journaltitle | JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | es |
dc.publication.volumen | 326 | es |
dc.publication.issue | 13 | es |
dc.publication.initialPage | 1277 | es |
dc.publication.endPage | 1285 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |