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dc.creatorMartínez Horta, Saules
dc.creatorBejr-Kasem, Helenaes
dc.creatorHorta Barba, Andreaes
dc.creatorPascual Sedano, Bertaes
dc.creatorSantos García, Diegoes
dc.creatorDeus Fonticoba, Teresa dees
dc.creatorMir Rivera, Pabloes
dc.creatorKulisevsky, Jaimees
dc.date.accessioned2022-11-28T14:14:45Z
dc.date.available2022-11-28T14:14:45Z
dc.date.issued2021-12-08
dc.identifier.citationMartínez Horta, S., Bejr-Kasem, H., Horta Barba, A., Pascual Sedano, B., Santos García, D., Deus Fonticoba, T., Mir Rivera, P., Kulisevsky, J. (2021). Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease. BMC Neurology, 21 (1), 477. https://doi.org/10.1186/s12883-021-02485-1.
dc.identifier.issn1471-2377es
dc.identifier.urihttps://hdl.handle.net/11441/139857
dc.description.abstractBackground Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005). Conclusions We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD.es
dc.formatapplication/pdfes
dc.format.extent10 p.es
dc.language.isoenges
dc.publisherBMCes
dc.relation.ispartofBMC Neurology, 21 (1), 477.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleIdentifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s diseasees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.publisherversionhttps://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02485-1es
dc.identifier.doi10.1186/s12883-021-02485-1es
dc.journaltitleBMC Neurologyes
dc.publication.volumen21es
dc.publication.issue1es
dc.publication.initialPage477es
dc.contributor.funderFundación Curemos el Parkinsones

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