dc.creator | Salazar-Rodríguez, Daniel | es |
dc.creator | Aleaga-Santiesteban, Yamilé | es |
dc.creator | Iglesias, Enrique | es |
dc.creator | Plascencia-Hernández, Arturo | es |
dc.creator | Pérez-Gómez, Héctor R. | es |
dc.creator | Calderón Sandubete, Enrique José | es |
dc.creator | Vázquez-Boland, José A. | es |
dc.creator | de Armas, Yaxsier | es |
dc.date.accessioned | 2022-11-21T12:30:42Z | |
dc.date.available | 2022-11-21T12:30:42Z | |
dc.date.issued | 2021-02-25 | |
dc.identifier.citation | Salazar-Rodríguez, D., Aleaga-Santiesteban, Y., Iglesias, E., Plascencia-Hernández, A., Pérez-Gómez, H.R., Calderón Sandubete, E.J.,...,de Armas, Y. (2021). Virulence plasmids of rhodococcus equi isolates from Cuban patients with AIDS. Frontiers in Veterinary Science, 8, 628239. https://doi.org/10.3389/fvets.2021.628239. | |
dc.identifier.issn | 2297-1769(electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/139625 | |
dc.description.abstract | Rhodococcus equi is an animal pathogen and zoonotic human opportunistic pathogen
associated with immunosuppressive conditions. The pathogenicity of R. equi is linked
to three animal host-associated virulence plasmids encoding a family of “Virulence
Associated Proteins” (VAPs). Here, the PCR-based TRAVAP molecular typing system
for the R. equi virulence plasmids was applied to 26 R. equi strains isolated between
2010 and 2016 at the Institute of Tropical Medicine “Pedro Kourí,” Cuba, from individuals
living with HIV/AIDS. TRAVAP detects 4 gene markers, traA common to the three
virulence plasmids, and vapA, vapB, and vapN specific to each of the host-associated
plasmid types (equine pVAPA, porcine pVAPB, and ruminant pVAPN). Of the 26 isolates,
six were positive to the vapB (porcine-type) marker, 4 (15.4%) to the vapA (equine-
type) marker, and 1 (3.8%) to the vapN (ruminant-type) marker. Most of the isolates
14 (53.8%) were negative to all TRAVAP markers, suggesting they lacked a virulence
plasmid. To our knowledge, this work is the first to report the molecular characterization
of R. equi isolates from Cuba. Our findings provide insight into the zoonotic origin of
R. equi infections in people and the potential dispensability of the virulence plasmid in
immunosuppressed patients. | es |
dc.format | application/pdf | es |
dc.format.extent | 4 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.relation.ispartof | Frontiers in Veterinary Science, 8, 628239. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Aids | es |
dc.subject | Animal host-associated virulence plasmids | es |
dc.subject | Cuba | es |
dc.subject | Human immunodeficiency virus | es |
dc.subject | R. equi zoonotic infection | es |
dc.subject | Rhodococcus equi | es |
dc.subject | TRAVAP virulence plasmid typing | es |
dc.title | Virulence plasmids of rhodococcus equi isolates from Cuban patients with AIDS | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fvets.2021.628239/full | es |
dc.identifier.doi | 10.3389/fvets.2021.628239 | es |
dc.journaltitle | Frontiers in Veterinary Science | es |
dc.publication.volumen | 8 | es |
dc.publication.initialPage | 628239 | es |