Artículo
CD46 Genetic Variability and HIV-1 Infection Susceptibility
Autor/es | Serrano Rísquez, Carmen
Omar, Mohamed Gómez Vidal, María Amparo Real, Luis Miguel Pineda Vergara, Juan Antonio Rivero, Antonio Caruz, Antonio |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021-11-09 |
Fecha de depósito | 2022-11-17 |
Publicado en |
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Resumen | CD46 is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. CD46 genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, ... CD46 is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. CD46 genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, CD46 function can be subverted by HIV-1 to evade attack by complement, a strategy shared by viruses of other families. We sought to determine the association between CD46 gene variants and HIV-1 acquired through intravenous drug use (IDU) and sexual routes (n = 823). Study subjects were of European ancestry and were HIV-1 infected (n = 438) or exposed but seronegative (n = 387). Genotyping of the rs2796265 SNP located in the CD46 gene region was done by allele-specific real-time PCR. A meta-analysis merging IDU and sexual cohorts indicates that the minor genotype (CC) was associated with increased resistance to HIV-1 infection OR = 0.2, 95% CI (0.07–0.61), p = 0.004. The HIV-1-protective genotype is correlated with reduced CD46 expression and alterations in the ratio of CD46 mRNA splicing isoforms. |
Agencias financiadoras | Ministerio de Economía, Industria y Competitividad de España SAF2016-80125-R Fondo Europeo de Desarrollo Regional |
Identificador del proyecto | SAF2016-80125-R
1381073-2020 |
Cita | Serrano Rísquez, C., Omar, M., Gómez Vidal, M.A., Real, L.M., Pineda Vergara, J.A., Rivero, A. y Caruz, A. (2021). CD46 Genetic Variability and HIV-1 Infection Susceptibility. Cells, 10 (11), 3094. https://doi.org/10.3390/cells10113094. |
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