Artículo
Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
Autor/es | Torres Macho, Juan
Sánchez Fernández, Marcos Arnanz González, Irene Tung-Chen, Yale Franco Moreno, Ana Isabel Duffort Falcó, Mercedes Beltrán Romero, Luis Matías Bernabeu Wittel, Máximo García Casasola, Gonzalo |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021-10-20 |
Fecha de depósito | 2022-11-07 |
Publicado en |
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Resumen | The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted ... The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (0–48 h and 72–96 h after admission) using a 10-zones sequence, and a 0 to 5 severity score. Primary combined endpoint was death or the need for invasive mechanical ventilation. Calibration (Hosmer–Lemeshow test and calibration curves), and discrimination power (area under the ROC curve) of both ultrasound exams (SCORE1 and 2), and their difference (DIFFERENTIAL-SCORE) were performed. A total of 469 patients (54.2% women, median age 60 years) were included. The primary endpoint occurred in 51 patients (10.9%). Probability risk tertiles of SCORE1 and SCORE2 (0–11 points, 12–24 points, and ≥25 points) obtained a high calibration. SCORE-2 showed a higher discrimination power than SCORE-1 (AUC 0.72 (0.58–0.85) vs. 0.61 (0.52–0.7)). The DIFFERENTIAL-SCORE showed a higher discrimination power than SCORE-1 and SCORE-2 (AUC 0.78 (0.66–0.9)). An algorithm for clinical decision-making is proposed. Serial lung ultrasound performing two examinations during the first days of hospitalization is an accurate strategy for predicting clinical deterioration of patients with COVID-19. |
Cita | Torres Macho, J., Sánchez Fernández, M., Arnanz González, I., Tung-Chen, Y., Franco Moreno, A.I., Duffort Falcó, M.,...,García Casasola, G. (2021). Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study). Journal of Clinical Medicine (JCM), 10 (21), 4818. https://doi.org/10.3390/jcm10214818. |
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