dc.creator | Domínguez-Domínguez, Lourdes | es |
dc.creator | Rava, Marta | es |
dc.creator | Bisbal, Otilia | es |
dc.creator | López Cortés, Luis Fernando | es |
dc.creator | Portilla, Joaquín | es |
dc.creator | Podzamczer, Daniel | es |
dc.creator | Moreno, Santiago | es |
dc.date.accessioned | 2022-11-07T15:13:47Z | |
dc.date.available | 2022-11-07T15:13:47Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Domínguez-Domínguez, L., Rava, M., Bisbal, O., López Cortés, L.F., Portilla, J., Podzamczer, D. y Moreno, S. (2022). Low CD4/CD8 ratio is associated with increased morbidity and mortality in late and non‑late presenters: results from a multicentre cohort study, 2004–2018. BMC INFECTIOUS DISEASES, 22 (11), 379. https://doi.org/10.1186/s12879-022-07352-z. | |
dc.identifier.issn | 1471-2334 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139087 | |
dc.description.abstract | Background: To study whether the association between the CD4/CD8 ratio variation over time and the develop‑
ment of clinical outcomes vary in late presenters (CD4 count<350/µL or AIDS event at enrolment) or advanced
presenters (CD4 count<200/µL or AIDS event at enrolment).
Methods: We included ART-naïve adults from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) enrolled
between January 2004 up to November 2018 and with at least 6 months of follow-up. We used extended Cox pro‑
portional hazard models to estimate the hazard ratios (HRs) for the association between CD4/CD8 ratio over time
and a composite endpoint of the occurrence of the frst AIDS event, frst serious non-AIDS event or overall mortality
occurring from 6 months after enrolment. HRs in non-late, late and advanced presenters were obtained by including
an interaction term between late presentation status and CD4/CD8 ratio over time.
Results: Of 10,018 participants, 55.6% were late presenters and 26.5% were advanced presenters. Compared with
CD4/CD8 ratio>0.4, CD4/CD8 ratio≤0.4 over time was associated with an increased risk of experiencing the compos‑
ite endpoint in non-late (HR 1.90; 95%CI 1.48, 2.43), late (HR 1.94; 1.46, 2.57) and advanced presenters (HR 1.72; 1.26,
2.34). Similarly, CD4/CD8 ratio≤0.4 over time was associated with a higher risk of developing an AIDS event (HR 3.31;
2.23, 4.93 in non-late; HR 2.75; 1.78, 4.27 in late and HR 2.25; 1.34, 3.76 in advanced presenters) or serious non-AIDS
event (HR 1.39; 0.96, 2.02 in non-late, HR 1.62; 1.10, 2.40 in late and HR 1.49; 0.97, 2.29 in advanced presenters) as well
as with a higher risk of overall mortality (HR 1.49; 0.92, 2.41 in non-late, HR 1.80; 1.04, 3.11 in late and HR 1.61; 0.92, 2.83
in advanced presenters) compared to CD4/CD8>0.4, regardless of the late presentation status.
Conclusions: A low CD4/CD8 measured over time is associated with increased risk of morbidity and mortality in
people living with HIV independently of their late presentation status. These data support the prognostic role of CD4/
CD8 over time and can help defning a subgroup of patients who need closer monitoring to avoid comorbidities. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Biomed Central LTD | es |
dc.relation.ispartof | BMC INFECTIOUS DISEASES, 22 (11), 379. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Late presentation | es |
dc.subject | CD4/CD8 | es |
dc.subject | Clinical outcomes | es |
dc.subject | AIDS events | es |
dc.subject | Serious non-AIDS events | es |
dc.subject | Mortality | es |
dc.title | Low CD4/CD8 ratio is associated with increased morbidity and mortality in late and non‑late presenters: results from a multicentre cohort study, 2004–2018 | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07352-z | es |
dc.identifier.doi | 10.1186/s12879-022-07352-z | es |
dc.contributor.group | Universidad de Sevilla. CTS203 : Estudio de las enfermedades infecciosas | es |
dc.journaltitle | BMC INFECTIOUS DISEASES | es |
dc.publication.volumen | 22 | es |
dc.publication.issue | 11 | es |
dc.publication.initialPage | 379 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |