dc.creator | Albasanz-Puig, Adaia | es |
dc.creator | Durà-Miralles, Xavier | es |
dc.creator | Laporte-Amargós, Júlia | es |
dc.creator | Mussetti, Alberto | es |
dc.creator | Ruiz-Camps, Isabel | es |
dc.creator | Puerta-Alcalde, Pedro | es |
dc.creator | Retamar Gentil, Pilar | es |
dc.creator | Gudiol, Carlota | es |
dc.date.accessioned | 2022-11-04T14:55:29Z | |
dc.date.available | 2022-11-04T14:55:29Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Albasanz-Puig, A., Durà-Miralles, X., Laporte-Amargós, J., Mussetti, A., Ruiz-Camps, I., Puerta-Alcalde, P.,...,Gudiol, C. (2022). Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia. Microorganisms, 10 (4), 733. https://doi.org/10.3390/microorganisms10040733. | |
dc.identifier.issn | 2076-2607 | es |
dc.identifier.uri | https://hdl.handle.net/11441/138987 | |
dc.description.abstract | To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate
in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a
multinational, retrospective cohort study of neutropenic onco-hematological patients with PA blood stream infection (BSI) (2006–2018). The effect of appropriate empirical combination therapy, appropri ate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was
assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia
was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant
(MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain
[38/52 (73.1%) vs. 30/242 (12.4%); p < 0.001]. The 30-day case-fatality rate was higher in patients
with PA bacteremic pneumonia than in those with PA BSI from other sources (55.1% vs. 31.4%;
p < 0.001). IEAT was associated with increased 30-day case-fatality (aHR 1.44 [95%CI 1.01–2.03];
p = 0.042), whereas the use of appropriate combination empirical treatment was independently
associated with improved survival (aHR 0.46 [95%CI 0.27–0.78]; p = 0.004). Appropriate empiri cal monotherapy was not associated with improved overall survival (aHR 1.25 [95%CI 0.76–2.05];
p = 0.39). Combination antibiotic empirical therapy should be administered promptly in febrile
neutropenic patients with suspected pneumonia as the source of infection. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Microorganisms, 10 (4), 733. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Pseudomonas aeruginosa | es |
dc.subject | Bloodstream infection | es |
dc.subject | Pneumonia | es |
dc.subject | Septic shock | es |
dc.subject | Neutropenia | es |
dc.title | Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.mdpi.com/2076-2607/10/4/733 | es |
dc.identifier.doi | 10.3390/microorganisms10040733 | es |
dc.journaltitle | Microorganisms | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 733 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | Ministerio de Economia, Industria y Competitividad (MINECO). España | es |