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dc.creatorKostyanev, T.es
dc.creatorXavier, B. B.es
dc.creatorGarcía-Castillo, M.es
dc.creatorLammens, C.es
dc.creatorBravo-Ferrer Acosta, J.es
dc.creatorRodríguez-Baño, Jesúses
dc.creatorCantón, Rafaeles
dc.creatorGlupczynski, Y.es
dc.creatorGoossens, H.es
dc.date.accessioned2022-11-02T15:03:47Z
dc.date.available2022-11-02T15:03:47Z
dc.date.issued2021
dc.identifier.citationKostyanev, T., Xavier, B.B., García-Castillo, M., Lammens, C., Bravo-Ferrer Acosta, J., Rodríguez-Baño, J.,...,Goossens, H. (2021). Phenotypic and molecular characterizations of carbapenem-resistant Acinetobacter baumannii isolates collected within the EURECA study. International Journal of Antimicrobial Agents, 57 (6), 106345. https://doi.org/10.1016/j.ijantimicag.2021.106345.
dc.identifier.issn0924-8579es
dc.identifier.issn1872-7913 (electrónico)es
dc.identifier.urihttps://hdl.handle.net/11441/138603
dc.description.abstractMulti-drug-resistant Acinetobacter baumannii isolates are key pathogens that contribute to the global bur den of antimicrobial resistance. This study aimed to investigate the phenotypic and molecular character istics of carbapenem-resistant A. baumannii (CRAB) isolates from the EURECA clinical trial. In total, 228 CRAB clinical strains were recovered from 29 sites in 10 European countries participating in the EURECA study between May 2016 and November 2018. All strains were reconfirmed centrally for identification and antimicrobial susceptibility testing, and were then subjected to DNA isolation and whole-genome sequencing (WGS), with analysis performed using BacPipe v.1.2.6. K and O typing was performed using KAPTIVE. Overall, 226 (99.1%) strains were confirmed as CRAB isolates. The minimum inhibitory con centration (MIC90) results of imipenem and meropenem were >16 mg/L. WGS showed that the isolates mainly harboured blaOXA-23 (n=153, 67.7%) or blaOXA-72 (n=70, 30.1%). Four blaOXA-72 isolates from Serbia co-harboured blaNDM-1. An IS5 transposase family element, ISAba31, was found upstream of the blaOXA-72 gene harboured on a small (~10-kb) pSE41030-EUR plasmid. The majority of isolates (n=178, 79.1%) be longed to international clone II. Strains belonging to the same sequence type but isolated in different countries or within the same country could be delineated in different clusters by core-genome multi locus sequence typing (MLST). Whole-genome/core-genome MLST showed high diversity among the iso lates, and the most common sequence type was ST2 (n=153, 67.7%). The EURECA A. baumannii strain collection represents a unique, diverse repository of carbapenem-resistant isolates that adds to the exist ing knowledge of A. baumannii epidemiology and resistance genes harboured by these strainses
dc.formatapplication/pdfes
dc.format.extent6 p.es
dc.language.isoenges
dc.publisherElsevier Sciencees
dc.relation.ispartofInternational Journal of Antimicrobial Agents, 57 (6), 106345.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAcinetobacter baumanniies
dc.subjectCarbapenem resistancees
dc.subjectWGSes
dc.subjectcg/wgMLSTes
dc.titlePhenotypic and molecular characterizations of carbapenem-resistant Acinetobacter baumannii isolates collected within the EURECA studyes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.projectIDREIPI RD16/0016/0001es
dc.relation.projectIDRD16/0016/0011es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S092485792100087X?via%3Dihubes
dc.identifier.doi10.1016/j.ijantimicag.2021.106345es
dc.journaltitleInternational Journal of Antimicrobial Agentses
dc.publication.volumen57es
dc.publication.issue6es
dc.publication.initialPage106345es
dc.contributor.funderInstituto de Salud Carlos IIIes
dc.contributor.funderSubdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidadeses

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