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dc.creatorVan Werkhoven, C. H.es
dc.creatorDucher, A.es
dc.creatorBerkell, M.es
dc.creatorMysara, M.es
dc.creatorLammens, C.es
dc.creatorTorre-Cisneros, J.es
dc.creatorRodríguez-Baño, Jesúses
dc.creatorVehreschild, M. J. G. T.es
dc.date.accessioned2022-10-24T15:09:45Z
dc.date.available2022-10-24T15:09:45Z
dc.date.issued2021
dc.identifier.citationVan Werkhoven, C.H., Ducher, A., Berkell, M., Mysara, M., Lammens, C., Torre-Cisneros, J.,...,Vehreschild, M.J.G.T. (2021). Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics. Nature Communications, 12 (1), 2240. https://doi.org/10.1038/s41467-021-22269-y.
dc.identifier.issn2041-1723es
dc.identifier.urihttps://hdl.handle.net/11441/138286
dc.description.abstractTrial enrichment using gut microbiota derived biomarkers by high-risk individuals can improve the feasibility of randomized controlled trials for prevention of Clostridioides difficile infection (CDI). Here, we report in a prospective observational cohort study the incidence of CDI and assess potential clinical characteristics and biomarkers to predict CDI in 1,007 patients ≥ 50 years receiving newly initiated antibiotic treatment with penicillins plus a beta lactamase inhibitor, 3rd/4th generation cephalosporins, carbapenems, fluoroquinolones or clindamycin from 34 European hospitals. The estimated 90-day cumulative incidences of a first CDI episode is 1.9% (95% CI 1.1-3.0). Carbapenem treatment (Hazard Ratio (95% CI): 5.3 (1.7-16.6)), toxigenic C. difficile rectal carriage (10.3 (3.2-33.1)), high intestinal abundance of Enterococcus spp. relative to Ruminococcus spp. (5.4 (2.1-18.7)), and low Shannon alpha diversity index as determined by 16 S rRNA gene profiling (9.7 (3.2-29.7)), but not nor malized urinary 3-indoxyl sulfate levels, predicts an increased CDI risk.es
dc.formatapplication/pdfes
dc.format.extent10 p.es
dc.language.isoenges
dc.publisherNature Publishing Groupes
dc.relation.ispartofNature Communications, 12 (1), 2240.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleIncidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibioticses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.publisherversionhttps://www.nature.com/articles/s41467-021-22269-yes
dc.identifier.doi10.1038/s41467-021-22269-yes
dc.contributor.groupUniversidad de Sevilla. CTS-406: Estudio enfermedades infecciosas en la práctica clínicaes
dc.journaltitleNature Communicationses
dc.publication.volumen12es
dc.publication.issue1es
dc.publication.initialPage2240es

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