dc.creator | Domínguez Castellano, Angel | es |
dc.date.accessioned | 2022-10-24T13:36:06Z | |
dc.date.available | 2022-10-24T13:36:06Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Domínguez Castellano, A. (2022). Tuberculosis and COVID-19 co-infection: description of the global cohort. EUROPEAN RESPIRATORY JOURNAL, 59 (3), 2102538. https://doi.org/10.1183/13993003.02538-2021. | |
dc.identifier.issn | 0903-1936 | es |
dc.identifier.issn | 1399-3003 | es |
dc.identifier.uri | https://hdl.handle.net/11441/138276 | |
dc.description.abstract | Background Information on tuberculosis (TB) and coronavirus disease 2019 (COVID-19) is still limited.
The aim of this study was to describe the features of the TB/COVID-19 co-infected individuals from a
prospective, anonymised, multicountry register-based cohort with special focus on the determinants of
mortality and other outcomes.
Methods We enrolled all patients of any age with either active TB or previous TB and COVID-19. 172
centres from 34 countries provided individual data on 767 TB-COVID-19 co-infected patients, (>50%
population-based).
Results Of 767 patients, 553 (74.0%) out of 747 had TB before COVID-19 (including 234 out of 747
with previous TB), 71 (9.5%) out of 747 had COVID-19 first and 123 (16.5%) out of 747 had both
diseases diagnosed within the same week (n=35 (4.6%) on the same day). 85 (11.08%) out of 767 patients
died (41 (14.2%) out of 289 in Europe and 44 (9.2%) out of 478 outside Europe; p=0.03): 42 (49.4%)
from COVID-19, 31 (36.5%) from COVID-19 and TB, one (1.2%) from TB and 11 from other causes. In
the univariate analysis on mortality the following variables reached statistical significance: age, male
gender, having more than one comorbidity, diabetes mellitus, cardiovascular disease, chronic respiratory
disease, chronic renal disease, presence of key symptoms, invasive ventilation and hospitalisation due to
COVID-19. The final multivariable logistic regression model included age, male gender and invasive
ventilation as independent contributors to mortality.
Conclusion The data suggest that TB and COVID-19 are a “cursed duet” and need immediate attention.
TB should be considered a risk factor for severe COVID disease and patients with TB should be prioritised
for COVID-19 preventative efforts, including vaccination. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p | es |
dc.language.iso | eng | es |
dc.publisher | EUROPEAN RESPIRATORY SOC JOURNALS LTD | es |
dc.relation.ispartof | EUROPEAN RESPIRATORY JOURNAL, 59 (3), 2102538. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Tuberculosis | es |
dc.subject | COVID-19 | es |
dc.title | Tuberculosis and COVID-19 co-infection: description of the global cohort | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://erj.ersjournals.com/content/59/3/2102538 | es |
dc.identifier.doi | 10.1183/13993003.02538-2021 | es |
dc.contributor.group | Universidad de Sevilla. CTS-406: Estudio Enfermedades Infecciosas en la Práctica Clínica. | es |
dc.journaltitle | EUROPEAN RESPIRATORY JOURNAL | es |
dc.publication.volumen | 59 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 2102538 | es |