Artículo
Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial
Autor/es | Rodríguez-Pardo, Dolors
Toro López, María Dolores del ![]() ![]() ![]() ![]() ![]() ![]() Guío-Carrión, Laura Escudero-Sánchez, Rosa Fernández-Sampedro, Marta García-Viejo, Miguel Ángel Pigrau, Carles |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-10-20 |
Publicado en |
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Resumen | Purpose To evaluate preoperative asymptomatic bacteriuria (ASB) treatment to reduce early-periprosthetic joint infections
(early-PJIs) after hip hemiarthroplasty (HHA) for fracture.
Methods Open-label, multicenter RCT ... Purpose To evaluate preoperative asymptomatic bacteriuria (ASB) treatment to reduce early-periprosthetic joint infections (early-PJIs) after hip hemiarthroplasty (HHA) for fracture. Methods Open-label, multicenter RCT comparing fosfomycin-trometamol versus no intervention with a parallel follow-up cohort without ASB. Primary outcome: early-PJI after HHA. Results Five hundred ninety-four patients enrolled (mean age 84.3); 152(25%) with ASB (77 treated with fosfomycin trometamol/75 controls) and 442(75%) without. Despite the study closed without the intended sample size, ASB was not predictive of early-PJI (OR: 1.06 [95%CI: 0.33–3.38]), and its treatment did not modify early-PJI incidence (OR: 1.03 [95%CI: 0.15–7.10]). Conclusions Neither preoperative ASB nor its treatment appears to be risk factors of early-PJI after HHA. ClinicalTrials.gov Identifier: Eudra CT 2016-001108-47 |
Agencias financiadoras | ISCIII-Subdirección General de Evaluación y Fomento de la Investigación Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad |
Identificador del proyecto | PI15/ 02161
![]() REIPI RD16/0016/0003 ![]() |
Cita | Rodríguez-Pardo, D., Toro López, M.D.d., Guío-Carrión, L., Escudero-Sánchez, R., Fernández-Sampedro, M., García-Viejo, M.Á. y Pigrau, C. (2021). Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial. European Journal of Clinical Microbiology & Infectious Diseases, 40 (11), 2411-2419. https://doi.org/10.1007/s10096-021-04241-2. |
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