dc.creator | Miravitlles, Marc | es |
dc.creator | Soler-Cataluña, Juan José | es |
dc.creator | Soriano, Joan B. | es |
dc.creator | García Río, Francisco | es |
dc.creator | Lucas, Pilar de | es |
dc.creator | Alfageme Michavila, Inmaculada | es |
dc.creator | Cosio, Borja | es |
dc.date.accessioned | 2022-10-19T15:00:34Z | |
dc.date.available | 2022-10-19T15:00:34Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Miravitlles, M., Soler-Cataluña, J.J., Soriano, J.B., García Río, F., Lucas, P.d., Alfageme Michavila, I. y Cosio, B. (2022). Determinants of blood eosinophil levels in the general population and patients with COPD: a population-based, epidemiological study. Respiratory Research, 23 (1), 49. https://doi.org/10.1186/s12931-022-01965-3. | |
dc.identifier.issn | 1465-993X | es |
dc.identifier.issn | 1465-9921 | es |
dc.identifier.uri | https://hdl.handle.net/11441/138126 | |
dc.description.abstract | Background: Blood eosinophils are considered a biomarker for the treatment of chronic obstructive pulmonary
disease (COPD). Population-based studies are needed to better understand the determinants of the blood eosinophil
count (BEC) in individuals with and without COPD.
Methods: EPISCAN II is a multicentre, cross-sectional, population-based epidemiological study aimed at investigating
the prevalence and determinants of COPD in Spain. Study subjects were randomly selected from the general popula‑
tion, and COPD was defned by a post-bronchodilator FEV1/FVC<0.7. For the pre-specifed outcomes related to BEC,
the frst 35 COPD and 35 non-COPD subjects were consecutively recruited in 12 of the participating centres with the
objective of analysing 400 individuals in each group. Baseline BEC and its association with demographic, clinical and
functional variables were analysed.
Results: A total of 326 COPD and 399 non-COPD subjects were included in the analysis. The mean age (standard
deviation [SD]) was 63.2 years (11.0), 46.3% were male, and 27.6% were active smokers. BEC was signifcantly higher in
individuals with COPD [192 cells/μL (SD: 125) vs. 160 cells/μL (SD: 114); p=0.0003]. In a stepwise multivariate model,
being male, active smoker and having a previous diagnosis of asthma were independently associated with having a
higher BEC.
Conclusions: This population-based study estimated the distribution of eosinophils in the healthy adult population
and concluded that COPD patients have a signifcantly higher BEC. Male sex, active smoking and concomitant asthma
were signifcantly associated with a higher BEC. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Biomed Central LTD | es |
dc.relation.ispartof | Respiratory Research, 23 (1), 49. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Epidemiology | es |
dc.subject | Computed tomography | es |
dc.subject | Imaging population | es |
dc.subject | Biomarkers | es |
dc.title | Determinants of blood eosinophil levels in the general population and patients with COPD: a population-based, epidemiological study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-01965-3 | es |
dc.identifier.doi | 10.1186/s12931-022-01965-3 | es |
dc.journaltitle | Respiratory Research | es |
dc.publication.volumen | 23 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 49 | es |