dc.creator | Pereyra-Rodríguez, José-Juan | es |
dc.creator | Domínguez Cruz, Javier | es |
dc.creator | Armario Hita, José Carlos | es |
dc.creator | Ruíz Villaverde, Ricardo | es |
dc.date.accessioned | 2022-10-10T13:43:50Z | |
dc.date.available | 2022-10-10T13:43:50Z | |
dc.date.issued | 2021-11 | |
dc.identifier.citation | Pereyra Rodríguez, J.J., Domínguez Cruz, J., Armario Hita, J.C. y Ruíz Villaverde, R. (2021). 104-week safety and effectiveness of dupilumab in the treatment of severe atopic dermatitis. The experience of 5 reference dermatology units in Spain. Anais Brasileiros de Dermatologia, 96 (6), 787-790. https://doi.org/10.1016/j.abd.2020.08.030. | |
dc.identifier.issn | 0365-0596;1806-4841 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137764 | |
dc.description.abstract | Atopic Dermatitis (AD) is a multifactorial disease resulting from the interaction of genetic predisposition, environmental triggers, disruption of skin barrier function, and type 2 immune dysregulation. Management of mild forms of AD includes the use of emollients, topical corticosteroids or calcineurin inhibitors, and phototherapy, while systemic immunosuppressive agents such as oral corticosteroids and Cyclosporine A (CsA) are reserved for severe refractory cases.1 Nevertheless, severe cases are usually not adequately controlled with any of these therapies, requiring a further step to reach clinical control.2 Recently, FDA and EMA have authorized Dupilumab, a treatment targeting Th2 cytokines Il-4 and Il-13 which has shown to be effective to control the signs and symptoms of AD. Real-world experience with Dupilumab shows a similar effectivity as compared to randomized clinical trials, but it is yet to know how this drug will perform in the long term in routine medical practice | es |
dc.format | application/pdf | es |
dc.format.extent | 4 p. | es |
dc.language.iso | eng | es |
dc.publisher | Sociedade Brasileira de Dermatologia. Elsevier | es |
dc.relation.ispartof | Anais Brasileiros de Dermatologia, 96 (6), 787-790. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Dupilumab | es |
dc.subject | Treatment of severe atopic dermatitis | es |
dc.title | 104-week safety and effectiveness of dupilumab in the treatment of severe atopic dermatitis. The experience of 5 reference dermatology units in Spain | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0365059621002300?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.abd.2020.08.030 | es |
dc.journaltitle | Anais Brasileiros de Dermatologia | es |
dc.publication.volumen | 96 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 787 | es |
dc.publication.endPage | 790 | es |