dc.creator | Jiménez Cortegana, Carlos | es |
dc.creator | Sánchez Jiménez, Flora | es |
dc.creator | Pérez Pérez, Antonio | es |
dc.creator | Álvarez, Nerissa | es |
dc.creator | Sousa, Alberto | es |
dc.creator | Cantón Bulnes, María Luisa | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.creator | Sánchez Margalet, Víctor | es |
dc.date.accessioned | 2022-10-06T14:02:58Z | |
dc.date.available | 2022-10-06T14:02:58Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Jiménez Cortegana, C., Sánchez Jiménez, F., Pérez Pérez, A., Álvarez, N., Sousa, A., Cantón Bulnes, M.L.,...,Sánchez Margalet, V. (2022). Low levels of granulocytic myeloid-derived suppressor cells may be a good marker of survival in the follow-up of patients with severe COVID-19. Frontiers in Immunology, 12, 1-10. https://doi.org/10.3389/fimmu.2021.801410. | |
dc.identifier.issn | 1664-3224 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137692 | |
dc.description.abstract | Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a
disease (coronavirus disease 2019, COVID-19) that may develop into a systemic disease with
immunosuppression and death in its severe form. Myeloid-derived suppressive cells (MDSCs)
are inhibitory cells that contribute to immunosuppression in patients with cancer and infection.
Increased levels of MDSCs have been found in COVID-19 patients, although their role in the
pathogenesis of severe COVID-19 has not been clarified. For this reason, we raised the
question whether MDSCs could be useful in the follow-up of patients with severe COVID-19 in
the intensive care unit (ICU). Thus, we monitored the immunological cells, including MDSCs, in
80 patients admitted into the ICU. After 1, 2, and 3 weeks, we examined for a possible
association with mortality (40 patients). Although the basal levels of circulating MDSCs did not
discriminate between the two groups of patients, the last measurement before the endpoint
(death or ICU discharge) showed that patients discharged alive from the ICU had lower levels
of granulocytic MDSCs (G-MDSCs), higher levels of activated lymphocytes, and lower levels of
exhausted lymphocytes compared with patients who had a bad evolution (death). In
conclusion, a steady increase of G-MDSCs during the follow-up of patients with severe
COVID-19 was found in those who eventually died. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A. | es |
dc.relation.ispartof | Frontiers in Immunology, 12, 1-10. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | SARS-CoV2 | es |
dc.subject | COVID-19 | es |
dc.subject | ICU | es |
dc.subject | MDSCs | es |
dc.subject | Tregs | es |
dc.subject | PD-1 | es |
dc.subject | OX40 | es |
dc.title | Low levels of granulocytic myeloid-derived suppressor cells may be a good marker of survival in the follow-up of patients with severe COVID-19 | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fimmu.2021.801410/full | es |
dc.identifier.doi | 10.3389/fimmu.2021.801410 | es |
dc.journaltitle | Frontiers in Immunology | es |
dc.publication.volumen | 12 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 10 | es |