dc.creator | Sanyal, Arun J. | es |
dc.creator | Anstee, Quentin M. | es |
dc.creator | Trauner, Michael | es |
dc.creator | Lawitz, Eric J. | es |
dc.creator | Abdelmalek, Manal F. | es |
dc.creator | Ding, Dora | es |
dc.creator | Romero Gómez, Manuel | es |
dc.creator | Myers, Robert P. | es |
dc.date.accessioned | 2022-10-05T15:13:28Z | |
dc.date.available | 2022-10-05T15:13:28Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sanyal, A.J., Anstee, Q.M., Trauner, M., Lawitz, E.J., Abdelmalek, M.F., Ding, D.,...,Myers, R.P. (2022). Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis. Hepatology, 75 (5), 1235-1246. https://doi.org/10.1002/hep.32204. | |
dc.identifier.issn | 0270-9139 | es |
dc.identifier.issn | 1527-3350 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137658 | |
dc.description.abstract | Background and Aims
Surrogate endpoints that predict complications are necessary for assessment and approval of NASH therapies. We assessed associations between histologic and noninvasive tests (NITs) of fibrosis with liver-related complications in patients with NASH cirrhosis.
Approach and Results
Patients with compensated cirrhosis due to NASH were enrolled in two placebo-controlled trials of simtuzumab and selonsertib. Liver fibrosis at baseline and week 48 (W48) was staged by NASH Clinical Research Network (CRN) and Ishak classifications and a machine learning (ML) approach, hepatic collagen and alpha-smooth muscle actin (α-SMA) expression were quantified by morphometry, liver stiffness (LS) was measured by transient elastography, and serum NITs (enhanced liver fibrosis [ELF], NAFLD fibrosis score [NFS], and Fibrosis-4 index [FIB-4]) were calculated. Cox regression determined associations between these parameters at baseline and their changes over time with adjudicated liver-related clinical events. Among 1,135 patients, 709 (62%) had Ishak stage 6 fibrosis, and median ELF and LS were 10.66 and 21.1 kPa, respectively. During a median follow-up of 16.6 months, 71 (6.3%) had a liver-related event; associated baseline factors included Ishak stage 6 fibrosis, and higher hepatic collagen, α-SMA expression, ML-based fibrosis parameters, LS, ELF, NFS, and FIB-4. Cirrhosis regression observed in 16% (176/1,135) between BL and W48 was associated with a lower risk of events versus nonregression (1.1% [2/176] vs. 7.2% [69/957]; HR, 0.16; 95% CI, 0.04, 0.65 [p = 0.0104]). Conversely, after adjustment for baseline values, increases in hepatic collagen, α-SMA, ML-based fibrosis parameters, NFS, and LS were associated with an increased risk of events.
Conclusions
In patients with compensated cirrhosis due to NASH, regression of fibrosis is associated with a reduction in liver-related complications. These data support the utility of histologic fibrosis regression and NITs as clinical trial endpoints for NASH cirrhosis. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | WILEY | es |
dc.relation.ispartof | Hepatology, 75 (5), 1235-1246. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cirrhosis regression | es |
dc.subject | Nonalcoholic steatohepatitis | es |
dc.title | Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.32204 | es |
dc.identifier.doi | 10.1002/hep.32204 | es |
dc.journaltitle | Hepatology | es |
dc.publication.volumen | 75 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1235 | es |
dc.publication.endPage | 1246 | es |