dc.creator | Jiménez Cortegana, Carlos | es |
dc.creator | Sánchez Martínez, Pilar M. | es |
dc.creator | Palazón Carrión, Natalia | es |
dc.creator | Nogales Fernández, Esteban | es |
dc.creator | Henao Carrasco, Fernando Manuel | es |
dc.creator | García Sancho, Alejandro Martín | es |
dc.creator | Rueda, Antonio | es |
dc.creator | Provencio, Mariano | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.creator | Sánchez Margalet, Víctor | es |
dc.date.accessioned | 2022-10-05T13:52:48Z | |
dc.date.available | 2022-10-05T13:52:48Z | |
dc.date.issued | 2021-09-15 | |
dc.identifier.citation | Jiménez Cortegana, C., Sánchez Martínez, P.M., Palazón Carrión, N., Nogales Fernández, E., Henao Carrasco, F.M., García Sancho, A.M.,...,Sánchez Margalet, V. (2021). Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial. Cancers, 13 (18), 4622. https://doi.org/10.3390/cancers13184622. | |
dc.identifier.issn | 2072-6694 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137648 | |
dc.description.abstract | The search of prognostic factors is a priority in diffuse large B-cell lymphoma (DLBCL)
due to its aggressiveness. We have recently found that the level of circulating MDSCs is a good
marker of survival in a translational study based on a trial (EudraCT Number: 2014-001620-29), using
lenalidomide combined with R-GDP (rituximab plus gemcitabine, cisplatin, and dexamethasone).
Since Vitamin D is a known immunomodulator, we have studied blood levels of these cell populations
comparing patients with deficit of vitamin D levels (<15 ng/mL with those with normal levels
>15 ng/mL. Mann–Whitney U test was used to compare cells distributions between groups, Wilcoxon
test to compare cells distribution at different times and Spearman test to measure the association
between cell populations. Patients with vitamin D deficit maintained the increased level of immune
suppressor cells, whereas we observed a depletion of all immune suppressor cells in patients with
normal vitamin D levels. In conclusion, we have confirmed the importance of vitamin D in the
response to treatment in R/R DLBCL, suggesting that vitamin D deficit may be involved in the
immune deficit of these patients, and thus, vitamin D supplementation in these patients may help to
obtain a better response, warranting further investigation. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Cancers, 13 (18), 4622. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Diffuse large B-cell lymphoma | es |
dc.subject | Immune system | es |
dc.subject | MDSC | es |
dc.subject | Treg | es |
dc.subject | PD-1 | es |
dc.subject | Vitamin D | es |
dc.subject | Immuno-suppression | es |
dc.subject | Lenalidomid | es |
dc.title | Lower Survival and Increased Circulating Suppressor Cells in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma with Deficit of Vitamin D Levels Using R-GDP Plus Lenalidomide (R2-GDP): Results from the R2-GDP-GOTEL Trial | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/13/18/4622/htm | es |
dc.identifier.doi | 10.3390/cancers13184622 | es |
dc.journaltitle | Cancers | es |
dc.publication.volumen | 13 | es |
dc.publication.issue | 18 | es |
dc.publication.initialPage | 4622 | |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina | |