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Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study
dc.creator | Navarrete-Muñoz, Eva Maria | es |
dc.creator | Vioque, Jesus | es |
dc.creator | Toledo, Estefanía | es |
dc.creator | Oncina-Canovas, Alejandro | es |
dc.creator | Martínez-González, Miguel Ángel | es |
dc.creator | Salas-Salvadó, Jordi | es |
dc.creator | Santos Lozano, José Manuel | es |
dc.creator | García-de-la-Hera, Manoli | es |
dc.date.accessioned | 2022-09-28T17:17:22Z | |
dc.date.available | 2022-09-28T17:17:22Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Navarrete-Muñoz, E.M., Vioque, J., Toledo, E., Oncina-Canovas, A., Martínez-González, M.Á., Salas-Salvadó, J.,...,García-de-la-Hera, M. (2021). Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study. European Journal of Nutrition, 60 (2), 1125-1136. | |
dc.identifier.issn | 1436-6207 | es |
dc.identifier.issn | 1436-6215 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137455 | |
dc.description.abstract | Purpose We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose–HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = − 0.12; 95% CI: − 0.19 to − 0.05), and plasma fasting glucose (β = − 0.03; 95% CI: − 0.05 to − 0.02) inde- pendently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04–0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subject | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer | es |
dc.relation.ispartof | European Journal of Nutrition, 60 (2), 1125-1136. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Folate | es |
dc.subject | Cardiometabolic risk | es |
dc.subject | Metabolic syndrome score | es |
dc.subject | Diabetes · | es |
dc.subject | Cholesterol | es |
dc.title | Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | http://doi.org/10.1007/s00394-020-02364-4 | es |
dc.identifier.doi | 10.1007/s00394-020-02364-4 | es |
dc.journaltitle | European Journal of Nutrition | es |
dc.publication.volumen | 60 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 1125 | es |
dc.publication.endPage | 1136 | es |