dc.creator | Díaz-López, Andrés | es |
dc.creator | Becerra-Tomás, Nerea | es |
dc.creator | Ruiz, Verónica | es |
dc.creator | Toledo, Estefania | es |
dc.creator | Babio, Nancy | es |
dc.creator | Corella, Dolores | es |
dc.creator | Santos Lozano, José Manuel | es |
dc.creator | Salas-Salvadó, Jordi | es |
dc.date.accessioned | 2022-09-28T15:16:10Z | |
dc.date.available | 2022-09-28T15:16:10Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Díaz-López, A., Becerra-Tomás, N., Ruiz, V., Toledo, E., Babio, N., Corella, D.,...,Salas-Salvadó, J. (2021). Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial. American Journal of Nephrology, 52 (1), 45-58. | |
dc.identifier.issn | 0250-8095 (impreso) | es |
dc.identifier.issn | 1421-9670 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/137440 | |
dc.description.abstract | Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled “PREvención con DIeta MEDiterránea-Plus” (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55–75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR (<60 mL/min/1.73 m2) and micro- to macroalbuminuria (UACR ≥30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m2) to mildly impaired GFR (60 to <90 mL/min/1.73 m2) or micro- to macroalbuminuria. Results: After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m2 in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m2; 95% CI: 0.15–1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44–0.82) and 92% higher (HR 1.92; 1.35–2.73), respectively, in the intervention group. Conclusions: The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | KARGER | es |
dc.relation.ispartof | American Journal of Nephrology, 52 (1), 45-58. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Dietary intervention | es |
dc.subject | Kidney function | es |
dc.subject | Mediterranean diet | es |
dc.subject | Weight loss | es |
dc.subject | Glomerular filtration rate | es |
dc.subject | PREDIMED-Plus | es |
dc.title | Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.karger.com/Article/FullText/513664 | es |
dc.identifier.doi | 10.1159/000513664 | es |
dc.journaltitle | American Journal of Nephrology | es |
dc.publication.volumen | 52 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 45 | es |
dc.publication.endPage | 58 | es |