Artículo
Sex Hormone Receptor Expression in Craniopharyngiomas and Association with Tumor Aggressiveness Characteristics
Autor/es | Martínez Ortega, Antonio Jesús
Flores Martínez, Álvaro Venegas-Moreno, Eva Dios, Elena Del Can, Diego Rivas, Eloy Soto Moreno, Alfonso Manuel Cano, David A. |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-09-27 |
Publicado en |
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Resumen | Craniopharyngiomas (CPs) are rare tumors of the sellar and suprasellar regions of embryonic origin. The primary treatment for CPs is surgery but it is often unsuccessful. Although CPs are considered benign tumors, they ... Craniopharyngiomas (CPs) are rare tumors of the sellar and suprasellar regions of embryonic origin. The primary treatment for CPs is surgery but it is often unsuccessful. Although CPs are considered benign tumors, they display a relatively high recurrence rate that might compromise quality of life. Previous studies have reported that CPs express sex hormone receptors, including estrogen and progesterone receptors. Here, we systematically analyzed estrogen receptor α (ERα) and progesterone receptor (PR) expression by immunohistochemistry in a well-characterized series of patients with CP (n = 41) and analyzed their potential association with tumor aggressiveness features. A substantial proportion of CPs displayed a marked expression of PR. However, most CPs expressed low levels of ERα. No major association between PR and ERα expression and clinical aggressiveness features was observed in CPs. Additionally, in our series, β-catenin accumulation was not related to tumor recurrence. |
Identificador del proyecto | PI16/00175 to A.S-M. and D.A.C.
A-0006-2017 and A-0055-2018 to A.S-M, RC-0006-2018 to D.A.C |
Cita | Martínez Ortega, A., Flores Martínez, Á., Venegas-Moreno, E., Dios, E., Del Can, D., Rivas, E.,...,Cano, D.A. (2022). Sex Hormone Receptor Expression in Craniopharyngiomas and Association with Tumor Aggressiveness Characteristics. Journal of Clinical Medicine, 11 (1), 1-9. |
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Sex Hormone.pdf | 14.62Mb | [PDF] | Ver/ | |