dc.creator | Gutman, Boris A. | es |
dc.creator | Van Erp, Theo G.M | es |
dc.creator | Tordesillas-Gutiérrez, Diana | es |
dc.creator | Crespo Facorro, Benedicto | es |
dc.creator | Setién Suero, Esther | es |
dc.creator | Wang, Lei | es |
dc.date.accessioned | 2022-09-15T16:39:21Z | |
dc.date.available | 2022-09-15T16:39:21Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Gutman, B.A., Van Erp, T.G.M., Tordesillas Gutiérrez, D., Crespo Facorro, B., Setién Suero, E. y Wang, L. (2022). A meta-analysis of deep brain structural shape and asymmetryabnormalities in 2,833 individuals with schizophreniacompared with 3,929 healthy volunteers via the ENIGMAConsortium. HUMAN BRAIN MAPPING, 43 (1), 352-372. | |
dc.identifier.issn | 1065-9471 | es |
dc.identifier.issn | 1097-0193 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137111 | |
dc.description.abstract | Schizophrenia is associated with widespread alterations in subcortical brain structure.While analytic methods have enabled more detailed morphometric characterization,findings are often equivocal. In this meta-analysis, we employed the harmonizedENIGMA shape analysis protocols to collaboratively investigate subcortical brainstructure shape differences between individuals with schizophrenia and healthy con-trol participants. The study analyzed data from 2,833 individuals with schizophreniaand 3,929 healthy control participants contributed by 21 worldwide research groupsparticipating in the ENIGMA Schizophrenia Working Group. Harmonized shape analy-sis protocols were applied to each site's data independently for bilateral hippocam-pus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained fromT1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens,and thalamus in individuals with schizophrenia compared with control participants,more-convex-than-concave shape differences in the putamen and pallidum, and bothconcave and convex shape differences in the caudate. Patterns of exaggerated asym-metry were observed across the hippocampus, amygdala, and thalamus in individualswith schizophrenia compared to control participants, while diminished asymmetryencompassed ventral striatum and ventral and dorsal thalamus. Our analyses also rev-ealed that higher chlorpromazine dose equivalents and increased positive symptomlevels were associated with patterns of contiguous convex shape differences acrossmultiple subcortical structures. Findings from our shape meta-analysis suggest thatcommon neurobiological mechanisms may contribute to gray matter reduction acrossmultiple subcortical regions, thus enhancing our understanding of the nature of net-work disorganization in schizophrenia. | es |
dc.format | application/pdf | es |
dc.format.extent | 21 p. | es |
dc.language.iso | eng | es |
dc.publisher | WILEY | es |
dc.relation.ispartof | HUMAN BRAIN MAPPING, 43 (1), 352-372. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Schizophrenia | es |
dc.subject | Structure | es |
dc.subject | Subcortical shape | es |
dc.title | A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psiquiatría | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/hbm.25625 | es |
dc.identifier.doi | 10.1002/hbm.25625 | es |
dc.journaltitle | HUMAN BRAIN MAPPING | es |
dc.publication.volumen | 43 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 352 | es |
dc.publication.endPage | 372 | es |