Artículo
A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium
Autor/es | Gutman, Boris A.
Van Erp, Theo G.M Tordesillas-Gutiérrez, Diana Crespo Facorro, Benedicto Setién Suero, Esther Wang, Lei |
Departamento | Universidad de Sevilla. Departamento de Psiquiatría |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-09-15 |
Publicado en |
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Resumen | Schizophrenia is associated with widespread alterations in subcortical brain structure.While analytic methods have enabled more detailed morphometric characterization,findings are often equivocal. In this meta-analysis, ... Schizophrenia is associated with widespread alterations in subcortical brain structure.While analytic methods have enabled more detailed morphometric characterization,findings are often equivocal. In this meta-analysis, we employed the harmonizedENIGMA shape analysis protocols to collaboratively investigate subcortical brainstructure shape differences between individuals with schizophrenia and healthy con-trol participants. The study analyzed data from 2,833 individuals with schizophreniaand 3,929 healthy control participants contributed by 21 worldwide research groupsparticipating in the ENIGMA Schizophrenia Working Group. Harmonized shape analy-sis protocols were applied to each site's data independently for bilateral hippocam-pus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained fromT1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens,and thalamus in individuals with schizophrenia compared with control participants,more-convex-than-concave shape differences in the putamen and pallidum, and bothconcave and convex shape differences in the caudate. Patterns of exaggerated asym-metry were observed across the hippocampus, amygdala, and thalamus in individualswith schizophrenia compared to control participants, while diminished asymmetryencompassed ventral striatum and ventral and dorsal thalamus. Our analyses also rev-ealed that higher chlorpromazine dose equivalents and increased positive symptomlevels were associated with patterns of contiguous convex shape differences acrossmultiple subcortical structures. Findings from our shape meta-analysis suggest thatcommon neurobiological mechanisms may contribute to gray matter reduction acrossmultiple subcortical regions, thus enhancing our understanding of the nature of net-work disorganization in schizophrenia. |
Cita | Gutman, B.A., Van Erp, T.G.M., Tordesillas Gutiérrez, D., Crespo Facorro, B., Setién Suero, E. y Wang, L. (2022). A meta-analysis of deep brain structural shape and asymmetryabnormalities in 2,833 individuals with schizophreniacompared with 3,929 healthy volunteers via the ENIGMAConsortium. HUMAN BRAIN MAPPING, 43 (1), 352-372. |
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