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dc.creatorMartak, Danieles
dc.creatorGuther, Juliaes
dc.creatorVerschuuren, Tess D.es
dc.creatorSalamanca, Elenaes
dc.creatorRodríguez-Baño, Jesúses
dc.creatorHocquet, Didieres
dc.date.accessioned2022-09-14T16:22:36Z
dc.date.available2022-09-14T16:22:36Z
dc.date.issued2022
dc.identifier.issn1198-743Xes
dc.identifier.issn1469-0691es
dc.identifier.urihttps://hdl.handle.net/11441/137071
dc.description.abstractObjectives To assess the extent to which food items are a source of extended-spectrum β-lactamase (ESBL) -producing Escherichia coli (ESBL-Ec) and ESBL-producing Klebsiella pneumoniae (ESBL-Kp) for humans in five European cities. Methods We sampled 122 human polluted (hp)-environments (sewers and polluted rivers, as a proxy of human contamination) and 714 food items in Besançon (France), Geneva (Switzerland), Sevilla (Spain), Tübingen (Germany) and Utrecht (The Netherlands). A total of 254 ESBL-Ec and 39 ESBL-Kp isolates were cultured. All genomes were fully sequenced to compare their sequence types (ST) and core genomes, along with the distribution of blaESBL genes and their genetic supports (i.e. chromosome or plasmid). Results Sequence data revealed that ESBL-Ec and ESBL-Kp isolates from hp-environments were genetically different from those contaminating food items. ESBL-Ec ST131 was widespread in the hp-environment (21.5% of the isolates) but absent from the food items tested. ESBL-Ec ST10 was in similar proportions in hp-environments and food items (15 and 10 isolates, respectively) but mostly carried reservoir-specific blaESBL. blaCTX-M-1 and blaSHV-12 predominated in food-related E. coli isolates (32% and 34% of the isolates, respectively), whereas blaCTX-M-15 and blaCTX-M-27 predominated in isolates from hp-environments (52% and 15% of the isolates, respectively). Conclusions We found a very limited connection between ESBL-Ec and ESBL-Kp populations retrieved in food items and from hp-environments and blaESBL. This suggests that human-to-human contamination, rather than the food chain, is possibly the most frequent route of ESBL-Ec and ESBL-Kp transmission in high-income countries.es
dc.formatapplication/pdfes
dc.format.extent8 p.es
dc.language.isoenges
dc.publisherElsevieres
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectExtended-spectrum b-lactamasees
dc.subjectEnvironmentes
dc.subjectEscherichia colies
dc.subjectFoodes
dc.subjectKlebsiella pneumoniaees
dc.titlePopulations of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae are different in human-polluted environment and food items: a multicentre European studyes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1198743X21004146?via%3Dihub#!es
dc.identifier.doi10.1016/j.cmi.2021.07.022es
dc.journaltitleWILEY-BLACKWELLes
dc.publication.volumen28es
dc.publication.issue3es
dc.publication.initialPage447.e7es
dc.publication.endPage447.e14es

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