dc.creator | Bullones Bolaños, Andrea Simone | es |
dc.creator | Bernal Bayard, Joaquín | es |
dc.creator | Ramos Morales, Francisco | es |
dc.date.accessioned | 2022-08-30T16:19:54Z | |
dc.date.available | 2022-08-30T16:19:54Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Bullones Bolaños, A.S., Bernal Bayard, J. y Ramos Morales, F. (2022). The NEL Family of Bacterial E3 Ubiquitin Ligases. International Journal of Molecular Sciences, 23 (14), 7725. | |
dc.identifier.issn | 1661-6596 | es |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/136545 | |
dc.description.abstract | Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination system of the eukaryotic host cell using a variety of strategies. Members of the genera Salmonella, Shigella, Sinorhizobium, and Ralstonia, among others, express E3 ubiquitin ligases that belong to the NEL family. These bacteria use type III secretion systems to translocate these proteins into host cells, where they will find their targets. In this review, we first introduce type III secretion systems and the ubiquitination process and consider the various ways bacteria use to alter the ubiquitin ligation machinery. We then focus on the members of the NEL family, their expression, translocation, and subcellular localization in the host cell, and we review what is known about the structure of these proteins, their function in virulence or symbiosis, and their specific targets. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2019-106132RB-I00/AEI/10.13039/501100011033 | es |
dc.description.sponsorship | Junta de Andalucía P20_00576 | es |
dc.description.sponsorship | Universidad de Sevilla US-1380805 | es |
dc.format | application/pdf | es |
dc.format.extent | 29 p. | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 23 (14), 7725. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | E3 ubiquitin ligases | es |
dc.subject | Effectors | es |
dc.subject | Ralstonia | es |
dc.subject | Salmonella | es |
dc.subject | Shigella | es |
dc.subject | Sinorhizobium | es |
dc.subject | Type III secretion | es |
dc.title | The NEL Family of Bacterial E3 Ubiquitin Ligases | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | PID2019-106132RB-I00/AEI/10.13039/501100011033 | es |
dc.relation.projectID | P20_00576 | es |
dc.relation.projectID | US-1380805 | es |
dc.relation.publisherversion | https://doi.org/10.3390/ijms23147725 | es |
dc.identifier.doi | 10.3390/ijms23147725 | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 23 | es |
dc.publication.issue | 14 | es |
dc.publication.initialPage | 7725 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Universidad de Sevilla | es |