dc.creator | Chui, D. H. | es |
dc.creator | Marcellino, Massimiliano | es |
dc.creator | Marotta, Francesco | es |
dc.creator | Sweed, H. | es |
dc.creator | Solimene, U. | es |
dc.creator | Vignali, A. I. | es |
dc.creator | Ayala Gómez, Antonio | es |
dc.creator | Zerbinati, Nicola | es |
dc.date.accessioned | 2022-08-11T11:01:35Z | |
dc.date.available | 2022-08-11T11:01:35Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Chui, D.H., Marcellino, M., Marotta, F., Sweed, H., Solimene, U., Vignali, A.I.,...,Zerbinati, N. (2014). A Double-Blind, RCT Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?. Journal of Clinical and Diagnosis Research, 8 (11), 1-6. | |
dc.identifier.issn | 2249-782X | es |
dc.identifier.issn | 0973-709X | es |
dc.identifier.uri | https://hdl.handle.net/11441/136152 | |
dc.description.abstract | Introduction: The aim of this prospective study was to see
whether LD-1227, a quality-controlled marine nutraceuticals
shown to protect experimental stress-induced hyppocampal
degeneration, could beneficially modulate BDNF, as measured in
the serum, in otherwise healthy but work-stressed individuals.
Materials and Methods: Forty-eight men and women between
the ages of 38 and 62 reporting high-demanding work activity
but with an overall positive attitude towards their personal life
were recruited. Subjects were divided in two group (24 patients
each) and blindly supplemented for 2 month with: a) LD-1227
400mg or b) placebo. A third group of healthy non-stressed
subjects was used as well. Blood samples were taken before
and after the supplementation period. Unstimulated saliva
was collected and tested for amylase while serum levels were
used to measure BDNF. State Trait Anxiety Inventory (STAI),
Pittsburgh Sleep Quality Index (PSQI) and psychological wellbeing assessment (PSWB) were measured too. Patients with
Val66Met functional polymorphism of BDNF excluded those
given their reported association with an impaired release of
BDNF.
Results: Results showed that, as compared to healthy, nonstressed individuals, stressed ones has a trend decrease
of BDNF and this was significantly increased by LD 12-1227
supplementation and the same inverse phenomenon occurred
to salivary amylase (p<0.05). No change was noted in the PSQI
score but, either STAI or PSWB tests scored better in LD-1227
supplemented subjects.
Conclusion: The present data suggest that LD-1227 is beneficially affecting neuromodulation and related symptoms during
common stressful life conditions and may have the potential as
tools in a neuroprotective clinical strategy. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 p. | es |
dc.language.iso | eng | es |
dc.publisher | JCDR | es |
dc.relation.ispartof | Journal of Clinical and Diagnosis Research, 8 (11), 1-6. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | LD-1227 | es |
dc.subject | Neurogenesis | es |
dc.subject | Neuroprotection | es |
dc.subject | Stress-induced neurodegeneration | es |
dc.title | A Double-Blind, RCT Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection? | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.publisherversion | https://dx.doi.org/10.7860/JCDR/2014/10301.5141 | es |
dc.identifier.doi | 10.7860/JCDR/2014/10301.5141 | es |
dc.journaltitle | Journal of Clinical and Diagnosis Research | es |
dc.publication.volumen | 8 | es |
dc.publication.issue | 11 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 6 | es |
dc.identifier.sisius | 20797767 | es |