dc.creator | García León, Juan Antonio | es |
dc.creator | Vitorica Ferrández, Francisco Javier | es |
dc.creator | Gutiérrez Pérez, Antonia | es |
dc.date.accessioned | 2022-07-04T11:15:32Z | |
dc.date.available | 2022-07-04T11:15:32Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | García León, J.A., Vitorica Ferrández, F.J. y Gutiérrez Pérez, A. (2019). Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform. Future Medicinal Chemistry, 11 (11), 1305-1322. | |
dc.identifier.issn | 1756-8919 | es |
dc.identifier.issn | 1756-8927 | es |
dc.identifier.uri | https://hdl.handle.net/11441/134962 | |
dc.description.abstract | Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies counteracting the disease progression. The advent of human pluripotent stem cells has revolutionized the field allowing the generation of disease-relevant neural cell types that can be used for disease modeling, drug screening and, possibly, cell transplantation purposes. In this Review, we discuss the applications of human pluripotent stem cells, the development of efficient protocols for the derivation of the different neural cells and their applicability for robust in vitro disease modeling and drug screening platforms for most common neurodegenerative conditions. | es |
dc.format | application/pdf | es |
dc.format.extent | 18 p. | es |
dc.language.iso | eng | es |
dc.publisher | Future Science Group | es |
dc.relation.ispartof | Future Medicinal Chemistry, 11 (11), 1305-1322. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Alzheimer’s disease | es |
dc.subject | amyotrophic lateral sclerosis | es |
dc.subject | CRISPR-Cas9 | es |
dc.subject | disease modeling | es |
dc.subject | drug screening | es |
dc.subject | hiP | es |
dc.title | Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.publisherversion | https://doi.org/10.4155/fmc-2018-0520 | es |
dc.identifier.doi | 10.4155/fmc-2018-0520 | es |
dc.journaltitle | Future Medicinal Chemistry | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 11 | es |
dc.publication.initialPage | 1305 | es |
dc.publication.endPage | 1322 | es |
dc.identifier.sisius | 21865452 | es |