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dc.creatorGarcia, Manones
dc.creatorKumanski, Sylvaines
dc.creatorElías Villalobos, Albertoes
dc.creatorCazevieille, Chantales
dc.creatorSoulet, Carolinees
dc.creatorMoriel Carretero, Maríaes
dc.date.accessioned2022-05-27T14:10:59Z
dc.date.available2022-05-27T14:10:59Z
dc.date.issued2022
dc.identifier.citationGarcia, M., Kumanski, S., Elías Villalobos, A., Cazevieille, C., Soulet, C. y Moriel Carretero, M. (2022). Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy. Life Science Alliance, 5 (9), e202101160.
dc.identifier.issn2575-1077es
dc.identifier.urihttps://hdl.handle.net/11441/133810
dc.description.abstractMembrane contact sites are functional nodes at which organelles reorganize metabolic pathways and adapt to changing cues. In Saccharomyces cerevisiae, the nuclear envelope subdomain surrounding the nucleolus, very plastic and prone to expansion, can establish contacts with the vacuole and be remodeled in response to various metabolic stresses. While using genotoxins with unrelated purposes, we serendipitously discovered a fully new remodeling event at this nuclear subdomain: the nuclear envelope partitions into its regular contact with the vacuole and a dramatic internalization within the nucleus. This leads to the nuclear engulfment of a globular, cytoplasmic portion. In spite of how we discovered it, the phenomenon is likely DNA damage-independent. We define lipids supporting negative curvature, such as phosphatidic acid and sterols, as bona fide drivers of this event. Mechanistically, we suggest that the engulfment of the cytoplasm triggers a suction phenomenon that enhances the docking of proton pump-containing vesicles with the vacuolar membrane, which we show matches a boost in autophagy. Thus, our findings unveil an unprecedented remodeling of the nucleolus-surrounding membranes with impact on metabolic adaptation.es
dc.description.sponsorshipFrench National Research Agency ANR-10-INBS-04es
dc.description.sponsorshipLa Ligue contre le Cancer et l’Institut National du Cancer PLBIO19- 098 INCA_13832es
dc.formatapplication/pdfes
dc.format.extent18 p.es
dc.language.isoenges
dc.publisherRockefeller University Presses
dc.relation.ispartofLife Science Alliance, 5 (9), e202101160.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleNuclear ingression of cytoplasmic bodies accompanies a boost in autophagyes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.projectIDANR-10-INBS-04es
dc.relation.projectIDPLBIO19- 098 INCA_13832es
dc.relation.publisherversionhttp://doi.org/10.26508/lsa.202101160es
dc.identifier.doi10.26508/lsa.202101160es
dc.journaltitleLife Science Alliancees
dc.publication.volumen5es
dc.publication.issue9es
dc.publication.initialPagee202101160es
dc.contributor.funderFrench National Research Agencyes
dc.contributor.funderLa Ligue contre le Cancer et l’Institut National du Cancer (France)es

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