dc.creator | Fernández Arche, María de los Ángeles | es |
dc.creator | Márquez Martín, Ana | es |
dc.creator | Puerta Vázquez, Rocío de la | es |
dc.creator | Perona, Javier S. | es |
dc.creator | Terencio, Carmen | es |
dc.creator | Pérez Camino, Carmen | es |
dc.creator | Ruiz Gutiérrez, Valentina | es |
dc.date.accessioned | 2022-05-23T18:32:17Z | |
dc.date.available | 2022-05-23T18:32:17Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Fernández Arche, M.d.l.Á., Márquez Martín, A., Puerta Vázquez, R.d.l., Perona, J.S., Terencio, C., Pérez Camino, C. y Ruiz Gutiérrez, V. (2009). Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators. Journal of Nutritional Biochemistry, 20 (3), 155-162. | |
dc.identifier.issn | 0955-2863 | es |
dc.identifier.issn | 1873-4847 | es |
dc.identifier.uri | https://hdl.handle.net/11441/133552 | |
dc.description.abstract | Pomace olive oil is a by-product of olive oil extraction that is traditionally produced and consumed in Spain. The nonglyceride matter of this oil is a good source of interesting minor compounds, like long-chain fatty alcohols, which are present free or as part of waxes. In the present study, long-chain fatty alcohols were isolated from the nonglyceride fraction of pomace olive oil, and the composition was identified and quantified. The major components of long-chain fatty alcohols were tetracosanol, hexacosanol and octacosanol. We investigated the ability of long-chain fatty alcohols from pomace olive oil to inhibit the release of different proinflammatory mediators in vitro by cells involved in inflammatory processes. Long-chain fatty alcohols significantly and dose-dependently decreased nitric oxide production by RAW 264.7 murine macrophages stimulated with lipopolysaccharide. Western blot analysis showed that nitric oxide reduction was a consequence of the inhibition of inducible nitric oxide synthetase expression. Long-chain fatty alcohols also reduced tumor necrosis factor-α and prostaglandin E2 production, although the potency of inhibition for the latter was lower. On the other hand, long-chain fatty alcohols significantly reduced thromboxane A2 production in rat peritoneal neutrophils stimulated with the calcium ionophore A-23187. The reduction of eicosanoid release was related to the inhibition of phospholipase A2 enzyme activity by long-chain fatty alcohols, reaching an inhibitory concentration 50% value of 6.2 μg/ml. These results showed that long-chain fatty alcohols may have a protective effect on some mediators involved in the inflammatory damage development, suggesting its potential value as a putative functional component of pomace olive oil. | es |
dc.format | application/pdf | es |
dc.format.extent | 24 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Journal of Nutritional Biochemistry, 20 (3), 155-162. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cytokine | es |
dc.subject | Inflammation | es |
dc.subject | Long-chain fatty alcohols | es |
dc.subject | Macrophages | es |
dc.subject | Nitric oxide | es |
dc.subject | Pomace olive oil | es |
dc.title | Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.jnutbio.2008.01.007 | es |
dc.identifier.doi | 10.1016/j.jnutbio.2008.01.007 | es |
dc.journaltitle | Journal of Nutritional Biochemistry | es |
dc.publication.volumen | 20 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 155 | es |
dc.publication.endPage | 162 | es |