Artículo
A rapid and versatile microfluidic method for the simultaneous extraction of polar and non-polar basic pharmaceuticals from human urine
Autor/es | Santigosa, Elia
Pedersen-Bjergaard, Stig Giménez Gómez, Pablo Muñoz, María Ramos Payán, María Dolores |
Departamento | Universidad de Sevilla. Departamento de Química Analítica |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-05-16 |
Publicado en |
|
Premios | Premio Mensual Publicación Científica Destacada de la US. Facultad de Química |
Resumen | In sample preparation, simultaneous extraction of analytes of very different polarity from biological matrixes represents a challenge. In this work, verapamil hydrochloride (VRP), amitriptyline (AMP), tyramine (TYR), ... In sample preparation, simultaneous extraction of analytes of very different polarity from biological matrixes represents a challenge. In this work, verapamil hydrochloride (VRP), amitriptyline (AMP), tyramine (TYR), atenolol (ATN), metopropol (MTP) and nortriptyline (NRP) were used as basic model analytes and simultaneously extracted from urine samples by liquid-phase microextraction (LPME) in a microfluidic device. The model analytes (target compounds) were pharmaceuticals with 0.4 < log P < 5. Different organic solvents and mixtures of them were investigated as supported liquid membrane (SLM), and a mixture of 2:1 (v/v) tributyl phosphate (TBP) and dihexyl ether (DHE) was found to be highly efficient for the simultaneous extraction of the non-polar and polar model analytes. TBP reduced the intrinsic hydrophobicity of the SLM and facilitated extraction of polar analytes, while DHE served to minimize trapping of non-polar analytes. Sample and acceptor phase composition were adjusted to pH 12 and pH 1.5, respectively. Urine samples were pumped into the microfluidic system at 1 μL min-1 and the extraction was completed in 7 min. Recoveries exceeded 78% for the target analytes, and the relative standard deviation (n = 4) was below 7% in all cases. Using five microliters of SLM, the microfluidic extraction system showed good long-term stability, and the same SLM was used for more than 18 consecutive extractions. |
Agencias financiadoras | Agencia de Gestió d'Ajusts Universitaris i the Recerca Agencia Estatal de Investigación. España |
Identificador del proyecto | 2017-SGR-329
PGC2018-096608-B-C21 |
Cita | Santigosa, E., Pedersen-Bjergaard, S., Giménez Gómez, P., Muñoz, M. y Ramos Payán, M.D. (2022). A rapid and versatile microfluidic method for the simultaneous extraction of polar and non-polar basic pharmaceuticals from human urine. Analytica Chimica Acta, 1208, 339829. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
A rapid and versatile microfluidic ... | 1.069Mb | [PDF] | Ver/ | |