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Development of porous silver nanoparticle/polycaprolactone/polyvinyl alcohol coatings for prophylaxis in titanium interconnected samples for dental implants
Author/s | Alcudia Cruz, Ana
![]() ![]() ![]() ![]() ![]() ![]() ![]() Begines Ruiz, Belén ![]() ![]() ![]() ![]() ![]() ![]() ![]() Rodríguez-Lejarraga, Paula Greyer, Valeria Fortio Godinho, Vanda Cristina Pajuelo Domínguez, Eloísa ![]() ![]() ![]() ![]() ![]() ![]() Torres Hernández, Yadir ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Department | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte Universidad de Sevilla. Departamento de Microbiología y Parasitología |
Publication Date | 2022-05 |
Deposit Date | 2022-04-22 |
Published in |
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Awards | Premio Mensual Publicación Científica Destacada de la US. Escuela Politécnica Superior |
Abstract | Stress shielding phenomenon, poor osseointegration, or bacterial infections of titanium dental implants are widely recognized as key problems that deeply affect their survival rate. In this work, a joint solution to solve ... Stress shielding phenomenon, poor osseointegration, or bacterial infections of titanium dental implants are widely recognized as key problems that deeply affect their survival rate. In this work, a joint solution to solve these three limitations is proposed. The first two issues were minimized applying porous Ti samples. This substrate exhibits an appropriated biomechanical equilibrium (stiffness and mechanical resistance) and good biofunctionality (ability to promote bone ingrowth). On the other hand, the porous Ti disc was coated with biocompatible and non-toxic polymeric composites matrices using poly-ε-caprolactone and partially acetylated polyvinyl alcohol, combined with silver nanoparticles as a therapeutic antimicrobial agent. The optimization of the best blend composition and optimal nanoparticles concentration were investigated. Finally, the two composites with the best antimicrobial activity were infiltrated into porous Ti discs. The deposited coatings presented good adhesion and a honeycomb-like surface structure that could promote vascularization of the implant and enhance osseointegration. |
Project ID. | PID2019-109371GB-I00
![]() P20_00671 ![]() US-1380878 ![]() PPI505/2020 ![]() PPI532/2020 ![]() |
Citation | Alcudia Cruz, A., Begines Ruiz, B., Rodríguez-Lejarraga, P., Greyer, V., Fortio Godinho, V.C., Pajuelo Domínguez, E. y Torres Hernández, Y. (2022). Development of porous silver nanoparticle/polycaprolactone/polyvinyl alcohol coatings for prophylaxis in titanium interconnected samples for dental implants. Colloid and Interface Science Communications, 48 (May), 100621-. |
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