dc.creator | Guo, Feifei | es |
dc.creator | Estévez-Vázquez, Esther | es |
dc.creator | Benedé-Ubieto, Raquel | es |
dc.creator | Ampuero Herrojo, Javier | es |
dc.creator | Romero Gómez, Manuel | es |
dc.creator | Nevzorova, Yulia A. | es |
dc.date.accessioned | 2022-03-28T15:48:50Z | |
dc.date.available | 2022-03-28T15:48:50Z | |
dc.date.issued | 2021-12-31 | |
dc.identifier.citation | Guo, F., Estévez-Vázquez, E., Benedé-Ubieto, R., Ampuero Herrojo, J., Romero Gómez, M. y Nevzorova, Y.A. (2021). A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy. Cancers, 14 (1) | |
dc.identifier.issn | 2072-6694 | es |
dc.identifier.uri | https://hdl.handle.net/11441/131367 | |
dc.description.abstract | Background: Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of human and murine MAFLD and MAFLD-associated HCC. Methods: alb-myctg mice were studied at baseline conditions and after administration of Western diet (WD) in comparison to WT littermates. c-MYC expression was analyzed in biopsies of patients with MAFLD and MAFLD-associated HCC by immunohistochemistry. Results: Mild obesity, spontaneous hyperlipidaemia, glucose intolerance and insulin resistance were characteristic of 36-week-old alb-myctg mice. Middle-aged alb-myctg exhibited liver steatosis and increased triglyceride content. Liver injury and inflammation were associated with elevated ALT, an upregulation of ER-stress response and increased ROS production, collagen deposition and compensatory proliferation. At 52 weeks, 20% of transgenic mice developed HCC. WD feeding exacerbated metabolic abnormalities, steatohepatitis, fibrogenesis and tumor prevalence. Therapeutic use of metformin partly attenuated the spontaneous MAFLD phenotype of alb-myctg mice. Importantly, upregulation and nuclear localization of c-MYC were characteristic of patients with MAFLD and MAFLD-related HCC. Conclusions: A novel function of c-MYC in MAFLD progression was identified opening new avenues for preventative strategies | es |
dc.description.sponsorship | MINECO Retos SAF2016-78711 | es |
dc.description.sponsorship | SAF2017-87919-R | es |
dc.description.sponsorship | PID2020-117827RB-IOO | es |
dc.description.sponsorship | PID2020-117941RB-IOO | es |
dc.description.sponsorship | PID2020-117116RB-I00 | es |
dc.description.sponsorship | EXOHEP-CM S2017/BMD- 3727 | es |
dc.description.sponsorship | NanoLiver-CM Y2018/NMT-4949 | es |
dc.description.sponsorship | AMMF 2018/117 | es |
dc.description.sponsorship | COST Action CA17112 | es |
dc.description.sponsorship | UCM-25/2019 | es |
dc.description.sponsorship | La Caixa Foundation Program HR17-00601 | es |
dc.description.sponsorship | Asociación Española Contra el Cáncer AECC PROYE20084 REGU | es |
dc.description.sponsorship | the German Research Foundation SFB1382 Project ID 403224013/A02 | es |
dc.description.sponsorship | Ramón y Cajal Researchers RYC-2014-15242 | es |
dc.description.sponsorship | RYC-2015-17438 | es |
dc.description.sponsorship | Instituto de Salud Carlos III PI16/01842, PI19/01404; PI19/00589 | es |
dc.description.sponsorship | The German Research Foundation SFB1382 Project ID 403224013/B07 | es |
dc.format | application/pdf | es |
dc.format.extent | 19 p. | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Cancers, 14 (1) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Metabolic-associated fatty liver disease (MAFLD) | es |
dc.subject | C-myc | es |
dc.subject | Oncogene | es |
dc.subject | Tumorigenesis | es |
dc.subject | Metformin | es |
dc.title | A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/14/1/192/htm | es |
dc.identifier.doi | 10.3390/cancers14010192 | es |
dc.journaltitle | Cancers | es |
dc.publication.volumen | 14 | es |
dc.publication.issue | 1 | es |