Artículo
Role of metformin and other metabolic drugs in the prevention and therapy of endocrine-related cancers
Autor/es | León González, Antonio José
Jiménez Vacas, Juan M. Fuentes Fayos, Antonio C. Sarmento Cabral, André Herrera Martínez, Aura D. Gahete, Manuel D. Luque, Raúl M. |
Departamento | Universidad de Sevilla. Departamento de Farmacología |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-03-23 |
Publicado en |
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Resumen | Metabolic syndrome is associated with chronic diseases, including type 2 diabetes, cardiovascular diseases, and cancer. This review summarizes the current evidence on the antitumor effects of some relevant drugs currently ... Metabolic syndrome is associated with chronic diseases, including type 2 diabetes, cardiovascular diseases, and cancer. This review summarizes the current evidence on the antitumor effects of some relevant drugs currently used to manage metabolic-related pathologies (i.e. insulin and its analogs, metformin, statins, etc.) in endocrine-related cancers including breast cancer, prostate cancer, pituitary cancer, ovarian cancer, and neuroendocrine neoplasms. Although current evidence does not provide a clear antitumor role of several of these drugs, metformin seems to be a promising chemopreventive and adjuvant agent in cancer management, modulating tumor cell metabolism and microenvironment, through both AMP-activated protein kinase-dependent and -independent mechanisms. Moreover, its combination with statins might represent a promising therapeutic strategy to tackle the progression of endocrine-related tumors. However, further studies are needed to endorse the clinical relevance of these drugs as adjuvants for cancer chemotherapy. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Fondo Social Europeo (FSE). E.U. Instituto de Salud Carlos III. España Junta de Andalucía |
Identificador del proyecto | PID2019- 105564RB-I00/FPU16-05059
PI20/01301 SCIII-AES-2019/002525 PI-0152-2019 PI-0094-2020 PI-0038/2019 RH-0084-2020 BIO-0139 |
Cita | León González, A.J., Jiménez Vacas, J.M., Fuentes Fayos, A.C., Sarmento Cabral, A., Herrera Martínez, A.D., Gahete, M.D. y Luque, R.M. (2021). Role of metformin and other metabolic drugs in the prevention and therapy of endocrine-related cancers. Current Opinion in Pharmacology, 60, 17-26. |
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