dc.creator | Tresserra-Rimbau, Anna | es |
dc.creator | Castro-Barquero, Sara | es |
dc.creator | Becerra-Tomás, Nerea | es |
dc.creator | Babio, Nancy | es |
dc.creator | Santos Lozano, José Manuel | es |
dc.creator | Salas-Salvadó, Jordi | es |
dc.date.accessioned | 2022-03-17T09:26:39Z | |
dc.date.available | 2022-03-17T09:26:39Z | |
dc.date.issued | 2022-02-04 | |
dc.identifier.citation | Tresserra-Rimbau, A., Castro-Barquero, S., Becerra-Tomás, N., Babio, N., Santos Lozano, J.M. y Salas-Salvadó, J. (2022). Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial. Antioxidants, 11 (2) | |
dc.identifier.issn | 2076-3921 | es |
dc.identifier.uri | https://hdl.handle.net/11441/130934 | |
dc.description.abstract | The prevalence of diabetes is experiencing an increasing trend, and in 2019 it was
the ninth leading cause of death in the world. Additionally, individuals with diabetes are
more likely to suffer from other noncommunicable diseases such as heart attacks, strokes,
or kidney disease. The expectations for the forthcoming years are not encouraging since
the prevalence of diabetes has been increasing over the past decades. Nevertheless, type-2
diabetes (T2D), the most prevalent type, can be prevented by modifying harmful behavioral
risk factors such as smoking, an unhealthy diet, sedentarism, and alcohol abuse [1]. In the
search for the best dietary pattern to prevent or stop the progression of T2D, plant-based
diets such as Mediterranean-style, vegetarian or vegan diets have been studied in several
prospective observational studies and clinical trials [2].
Healthy plant-based diets are based on the consumption of large amounts of whole
grains, fruits, vegetables, legumes, and nuts, as well as healthy fats such as extra virgin
olive oil, which are associated with a lower risk of developing cardiovascular disease and
T2D [3]. A trait all these foods have in common is a richness in polyphenols, bioactive
plant secondary metabolites with a vast structural diversity. According to their structure,
polyphenols are classified into two main groups: flavonoids and non-flavonoids. Polyphe nols in the flavonoid group share the C6-C3-C6 structure and can be divided into the
following subgroups: flavones, flavonols, theaflavins, catechins, proanthocyanidins (poly meric forms), flavanones, anthocyanidins, and isoflavones, whereas the non-flavanoids are
classified as phenolic acids, lignans, and stilbenes [4].
Protective effects of polyphenols against the incidence and complications of T2D
are supported by mechanistic studies conducted in animals [5] as well as clinical and
epidemiological studies [6], although the available evidence is still limited and inconsistent.
Furthermore, no previous study has examined the association between changes in the intake
of all polyphenolic groups and subgroups and T2D-related parameters in a population with
or at high-risk of T2D. The aim of the present work was to determine whether changing
to a high polyphenol diet is associated with an improved glucose profile. Due to the
heterogeneity of polyphenols in terms of bioavailability and metabolism, they were studied
in separate groups. | es |
dc.format | application/pdf | es |
dc.format.extent | 21 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Antioxidants, 11 (2) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Antioxidants | es |
dc.subject | Mediterranean diet | es |
dc.subject | Flavonoids | es |
dc.subject | Phenolic acids | es |
dc.subject | Obesity | es |
dc.subject | Glucose | es |
dc.subject | HbA1c | es |
dc.subject | Glycosylated hemoglobin | es |
dc.subject | Metabolic syndrome | es |
dc.title | Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.mdpi.com/journal/antioxidants | es |
dc.identifier.doi | 10.3390/antiox11020316 | es |
dc.journaltitle | Antioxidants | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 2 | es |