dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | Naranjo, Maria C. | es |
dc.creator | López Martín, Sergio | es |
dc.creator | Abia González, María del Rocío | es |
dc.creator | García Muriana, Francisco José | es |
dc.creator | Bermúdez Pulgarín, Beatriz | es |
dc.date.accessioned | 2022-03-14T16:06:38Z | |
dc.date.available | 2022-03-14T16:06:38Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Montserrat de la Paz, S., Naranjo, M.C., López Martín, S., Abia González, M.d.R., García Muriana, F.J. y Bermúdez Pulgarín, B. (2016). Olive oil, compared to a saturated dietary fat, has a protective role on atherosclerosis in niacin-treated mice with metabolic syndrome. Journal of Functional Foods, 26, 557-564. | |
dc.identifier.issn | 1756-4646 | es |
dc.identifier.uri | https://hdl.handle.net/11441/130764 | |
dc.description.abstract | We aimed to investigate the impact of high-fat low-cholesterol diets rich in saturated fatty acids (HFLCD-SFAs), monounsaturated FAs (HFLCD-MUFAs) or MUFAs + omega-3 long-chain polyunsaturated FAs (HFLCD-PUFAs) in combination with niacin (NA) on atherosclerotic plaque characteristics in a mouse model (Lepob/obLDLR−/−) of metabolic syndrome (MetS). Compared to a low-fat low-cholesterol diet (LFLCD), HFLCDs increased body weight, triglycerides, insulin, pro-inflammatory cytokines, and circulating monocytes, contributing the HFLCD-SFAs to a predominance of a classical pro-inflammatory Ly6Chi population, whereas HFLCD-MUFAs and HFLCD-PUFAs to a non-classical patrolling Ly6Clo population. HFLCDs promoted atherosclerosis in the aortic roots of animals but the plaque size, collagen, and macrophage content were higher with the HFLCD-SFAs than with the HFLCD-MUFAs or HFLCD-PUFAs. Furthermore, HFLCD-SFAs promoted the intra-plaque accumulation of M1 macrophages, whereas HFLCD-MUFAs and HFLCD-PUFAs favoured the accumulation of M2 macrophages. These data suggest that dietary MUFAs had advantage over SFAs to prevent atherosclerotic events in the NA-treated MetS. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación AGL2011-29008 | es |
dc.format | application/pdf | es |
dc.format.extent | 29 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Journal of Functional Foods, 26, 557-564. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Atherosclerosis | es |
dc.subject | Macrophages | es |
dc.subject | Metabolic syndrome | es |
dc.subject | Monocytes | es |
dc.subject | Monounsaturated fatty acids | es |
dc.subject | Niacin | es |
dc.title | Olive oil, compared to a saturated dietary fat, has a protective role on atherosclerosis in niacin-treated mice with metabolic syndrome | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.projectID | AGL2011-29008 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.jff.2016.08.028 | es |
dc.identifier.doi | 10.1016/j.jff.2016.08.028 | es |
dc.journaltitle | Journal of Functional Foods | es |
dc.publication.volumen | 26 | es |
dc.publication.initialPage | 557 | es |
dc.publication.endPage | 564 | es |