dc.creator | Martín Rubio, María Esther | es |
dc.creator | Millán-Linares, María del Carmen | es |
dc.creator | Naranjo, María C. | es |
dc.creator | Toscano Sánchez, María del Rocío | es |
dc.creator | Abia González, María del Rocío | es |
dc.creator | García Muriana, Francisco José | es |
dc.creator | Bermúdez Pulgarín, Beatriz | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.date.accessioned | 2022-03-14T14:55:48Z | |
dc.date.available | 2022-03-14T14:55:48Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Martín Rubio, M.E., Millán Linares, M.C., Naranjo, M.C., Toscano Sánchez, M.d.R., Abia González, M.d.R., García Muriana, F.J.,...,Montserrat de la Paz, S. (2019). Minor compounds from virgin olive oil attenuate LPS-induced inflammation via visfatin-related gene modulation on primary human monocytes. Journal of Food Biochemistry, 43 (8), e12941. | |
dc.identifier.issn | 0145-8884 | es |
dc.identifier.issn | 1745-4514 | es |
dc.identifier.uri | https://hdl.handle.net/11441/130760 | |
dc.description.abstract | We have analyzed the effects of minor compounds found in the unsaponifiable fraction (UF) and in the phenolic fraction (PF) of virgin olive oil (VOO) on LPS-induced inflammatory response via visfatin modulation in human monocytes. For this purpose, monocytes were incubated with UF and PF at different concentrations and the pro-inflammatory stimulus LPS for 24 hr; squalene (SQ) and hydroxytyrosol (HTyr), the main components in UF and PF, respectively, were also used. The relative expression of both pro-inflammatory and anti-inflammatory genes, as well as other genes related to the NAD+-biosynthetic pathway was evaluated by RT-qPCR; and the secretion of some of these markers was assessed by ELISA procedures. We found that UF, SQ, PF, and HTyr prevented from LPS-induced dysfunctional gene expression and secretion via visfatin-related gene modulation in human monocytes. These findings unveil a potential beneficial role for minor compounds of VOO in the prevention of inflammatory-disorders. Practical application: In this project, potential health benefits of VOO micronutrients (unsaponifiable and phenolic compounds) were confirmed through anti-inflammatory assays. Our results reveal new interesting researching goals concerning nutrition by considering the role of bioactive VOO compounds in the prevention and progress of diseases related to inflammation. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | Journal of Food Biochemistry, 43 (8), e12941. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | NAMPT | es |
dc.subject | Olive oil | es |
dc.subject | Phenols | es |
dc.subject | Unsaponifiable | es |
dc.subject | Visfatin | es |
dc.title | Minor compounds from virgin olive oil attenuate LPS-induced inflammation via visfatin-related gene modulation on primary human monocytes | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.publisherversion | https://doi.org/10.1111/jfbc.12941 | es |
dc.identifier.doi | 10.1111/jfbc.12941 | es |
dc.journaltitle | Journal of Food Biochemistry | es |
dc.publication.volumen | 43 | es |
dc.publication.issue | 8 | es |
dc.publication.initialPage | e12941 | es |