dc.creator | Pérez Aranda, María | es |
dc.creator | Alcudia Cruz, Ana | es |
dc.creator | Begines Ruiz, Belén | es |
dc.creator | Pajuelo Domínguez, Eloísa | es |
dc.creator | Rodríguez Llorente, Ignacio David | es |
dc.creator | Martínez Muñoz, Guillermo | es |
dc.creator | Martín Valero, María Jesús | es |
dc.creator | Navarro de la Torre, Salvadora | es |
dc.date.accessioned | 2022-03-09T09:56:52Z | |
dc.date.available | 2022-03-09T09:56:52Z | |
dc.date.issued | 2020-04 | |
dc.identifier.citation | Pérez Aranda, M., Alcudia Cruz, A.,...,Navarro de la Torre, S. (2020). Looking for new compounds to battle antibiotic resistance: optimization of organic solvents. En La investigación de hoy, el futuro de mañana (pp. 61-65). Alcoy (Alicante): 3ciencias. | |
dc.identifier.isbn | 978-84-121459-2-2 | es |
dc.identifier.uri | https://hdl.handle.net/11441/130589 | |
dc.description.abstract | A high number of pathogens have shown the capacity of resist to the action of
antibiotics. This fact presents a very important problem to public health and highlights
the necessity of looking for new substances as alternative to antibiotics.
Since some of these substances have a hydrophobic nature they need to be solved in
organic solvents. Some of these solvents are also toxic to bacteria, mainly affecting
membranes. For these reasons it is necessary to perform a study of the toxicity of
organic solvents to bacteria, which has been the aim of this work.
Five organic solvents, DMF (dimethylformamide), TBME (tert-butyl methyl ether),
THF (tetrahydrofuran), DMSO (dimethyl sulfoxide) and CH2Cl2 (dichloromethane),
have been tested, using two of the most prevalent pathogens (Staphylococcus
pseudintermedius and Pseudomonas aeruginosa,) both in animals and humans.
The results show that, when possible, DMSO followed by TBME are the best options
for testing new compounds in Staphylococcus pseudintermedius, whether DMF
followed by TBME are the preferred solvents for testing hydrophobic compounds in
Pseudomonas aeruginosa. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | 3ciencias | es |
dc.relation.ispartof | La investigación de hoy, el futuro de mañana | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Looking for new compounds to battle antibiotic resistance: optimization of organic solvents | es |
dc.type | info:eu-repo/semantics/bookPart | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología y Parasitología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Analítica | es |
dc.relation.publisherversion | https://www.3ciencias.com/libros/libro/la-investigacion-de-hoy-el-futuro-de-manana/ | es |
dc.identifier.doi | 10.17993/IngyTec.2020.61 | es |
dc.contributor.group | Universidad de Sevilla. FQM135: Carbohidratos y Polímeros | es |
dc.contributor.group | Universidad de Sevilla. BIO181: Fitomicrobiomas como herramientas biotecnológicas | es |
dc.contributor.group | Universidad de Sevilla. FQM291: Análisis Químico | es |
dc.publication.initialPage | 61 | es |
dc.publication.endPage | 65 | es |
dc.relation.publicationplace | Alcoy (Alicante) | es |