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dc.creatorPérez Aranda, Maríaes
dc.creatorAlcudia Cruz, Anaes
dc.creatorBegines Ruiz, Belénes
dc.creatorPajuelo Domínguez, Eloísaes
dc.creatorRodríguez Llorente, Ignacio Davides
dc.creatorMartínez Muñoz, Guillermoes
dc.creatorMartín Valero, María Jesúses
dc.creatorNavarro de la Torre, Salvadoraes
dc.date.accessioned2022-03-09T09:56:52Z
dc.date.available2022-03-09T09:56:52Z
dc.date.issued2020-04
dc.identifier.citationPérez Aranda, M., Alcudia Cruz, A.,...,Navarro de la Torre, S. (2020). Looking for new compounds to battle antibiotic resistance: optimization of organic solvents. En La investigación de hoy, el futuro de mañana (pp. 61-65). Alcoy (Alicante): 3ciencias.
dc.identifier.isbn978-84-121459-2-2es
dc.identifier.urihttps://hdl.handle.net/11441/130589
dc.description.abstractA high number of pathogens have shown the capacity of resist to the action of antibiotics. This fact presents a very important problem to public health and highlights the necessity of looking for new substances as alternative to antibiotics. Since some of these substances have a hydrophobic nature they need to be solved in organic solvents. Some of these solvents are also toxic to bacteria, mainly affecting membranes. For these reasons it is necessary to perform a study of the toxicity of organic solvents to bacteria, which has been the aim of this work. Five organic solvents, DMF (dimethylformamide), TBME (tert-butyl methyl ether), THF (tetrahydrofuran), DMSO (dimethyl sulfoxide) and CH2Cl2 (dichloromethane), have been tested, using two of the most prevalent pathogens (Staphylococcus pseudintermedius and Pseudomonas aeruginosa,) both in animals and humans. The results show that, when possible, DMSO followed by TBME are the best options for testing new compounds in Staphylococcus pseudintermedius, whether DMF followed by TBME are the preferred solvents for testing hydrophobic compounds in Pseudomonas aeruginosa.es
dc.formatapplication/pdfes
dc.format.extent5 p.es
dc.language.isoenges
dc.publisher3cienciases
dc.relation.ispartofLa investigación de hoy, el futuro de mañanaes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleLooking for new compounds to battle antibiotic resistance: optimization of organic solventses
dc.typeinfo:eu-repo/semantics/bookPartes
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Orgánica y Farmacéuticaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Microbiología y Parasitologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Analíticaes
dc.relation.publisherversionhttps://www.3ciencias.com/libros/libro/la-investigacion-de-hoy-el-futuro-de-manana/es
dc.identifier.doi10.17993/IngyTec.2020.61es
dc.contributor.groupUniversidad de Sevilla. FQM135: Carbohidratos y Polímeroses
dc.contributor.groupUniversidad de Sevilla. BIO181: Fitomicrobiomas como herramientas biotecnológicases
dc.contributor.groupUniversidad de Sevilla. FQM291: Análisis Químicoes
dc.publication.initialPage61es
dc.publication.endPage65es
dc.relation.publicationplaceAlcoy (Alicante)es

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