Capítulo de Libro
Looking for new compounds to battle antibiotic resistance: optimization of organic solvents
Autor/es | Pérez Aranda, María
Alcudia Cruz, Ana Begines Ruiz, Belén Pajuelo Domínguez, Eloísa Rodríguez Llorente, Ignacio David Martínez Muñoz, Guillermo Martín Valero, María Jesús Navarro de la Torre, Salvadora |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica Universidad de Sevilla. Departamento de Microbiología y Parasitología Universidad de Sevilla. Departamento de Química Analítica |
Fecha de publicación | 2020-04 |
Fecha de depósito | 2022-03-09 |
Publicado en |
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ISBN/ISSN | 978-84-121459-2-2 |
Resumen | A high number of pathogens have shown the capacity of resist to the action of
antibiotics. This fact presents a very important problem to public health and highlights
the necessity of looking for new substances as ... A high number of pathogens have shown the capacity of resist to the action of antibiotics. This fact presents a very important problem to public health and highlights the necessity of looking for new substances as alternative to antibiotics. Since some of these substances have a hydrophobic nature they need to be solved in organic solvents. Some of these solvents are also toxic to bacteria, mainly affecting membranes. For these reasons it is necessary to perform a study of the toxicity of organic solvents to bacteria, which has been the aim of this work. Five organic solvents, DMF (dimethylformamide), TBME (tert-butyl methyl ether), THF (tetrahydrofuran), DMSO (dimethyl sulfoxide) and CH2Cl2 (dichloromethane), have been tested, using two of the most prevalent pathogens (Staphylococcus pseudintermedius and Pseudomonas aeruginosa,) both in animals and humans. The results show that, when possible, DMSO followed by TBME are the best options for testing new compounds in Staphylococcus pseudintermedius, whether DMF followed by TBME are the preferred solvents for testing hydrophobic compounds in Pseudomonas aeruginosa. |
Cita | Pérez Aranda, M., Alcudia Cruz, A.,...,Navarro de la Torre, S. (2020). Looking for new compounds to battle antibiotic resistance: optimization of organic solvents. En La investigación de hoy, el futuro de mañana (pp. 61-65). Alcoy (Alicante): 3ciencias. |
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