| dc.creator | Jaramillo Carmona, Sara | es |
| dc.creator | Guillén Bejarano, Rafael | es |
| dc.creator | Jiménez Araujo, Ana José | es |
| dc.creator | Rodríguez Arcos, Rocío | es |
| dc.creator | López Martín, Sergio | es |
| dc.date.accessioned | 2022-03-08T16:48:48Z | |
| dc.date.available | 2022-03-08T16:48:48Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Jaramillo Carmona, S., Guillén Bejarano, R., Jiménez Araujo, A.J., Rodríguez Arcos, R. y López Martín, S. (2018). In Vitro Toxicity of Asparagus Saponins in Distinct Multidrug-Resistant Colon Cancer Cells. Chemistry and Biodiversity, 15 (11), e1800282. | |
| dc.identifier.issn | 1612-1872 | es |
| dc.identifier.issn | 1612-1880 | es |
| dc.identifier.uri | https://hdl.handle.net/11441/130542 | |
| dc.description.abstract | Colorectal cancer is the third most common cancer in the world. Many efforts have focused on finding natural molecules with potential chemo-preventive activity due to their low toxicity compared to synthetic drugs. However, comprehensive information on the bioactive fractions and components is still missing. In this study, we developed a method for the quantitative separation and isolation of saponins from asparagus genotypes consisting of an adsorption chromatography and subsequent liquid chromatographic separation on a reversed-phase column. The saponins isolated were tested for their cytotoxic activity against human colon cancer cell lines, which could develop cross-resistance to a wide variety of chemotherapeutic drugs. Our results showed that Huétor-Tájar asparagus saponins (HTSAP), mainly protodioscin and HTSAP-10 have higher cytotoxic activity than HTSAP-1, HTSAP-6, and HTSAP-8. This study links the potential anticancer effect of asparagus to specific saponins and unveils the triguero Huétor-Tájar asparagus as a nutraceutical particularly in colon cancer therapies | es |
| dc.description.sponsorship | Ministerio de Economía y Competitividad JCI-2012-13084 | es |
| dc.format | application/pdf | es |
| dc.format.extent | 9 p. | es |
| dc.language.iso | eng | es |
| dc.publisher | Wiley-Blackwell | es |
| dc.relation.ispartof | Chemistry and Biodiversity, 15 (11), e1800282. | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | Asparagus | es |
| dc.subject | Biological activity | es |
| dc.subject | Colon cancer cells | es |
| dc.subject | Cytotoxicity | es |
| dc.subject | Saponins | es |
| dc.title | In Vitro Toxicity of Asparagus Saponins in Distinct Multidrug-Resistant Colon Cancer Cells | es |
| dc.type | info:eu-repo/semantics/article | es |
| dcterms.identifier | https://ror.org/03yxnpp24 | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | es |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
| dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Celular | es |
| dc.relation.projectID | JCI-2012-13084 | es |
| dc.relation.publisherversion | https://doi.org/10.1002/cbdv.201800282 | es |
| dc.identifier.doi | 10.1002/cbdv.201800282 | es |
| dc.journaltitle | Chemistry and Biodiversity | es |
| dc.publication.volumen | 15 | es |
| dc.publication.issue | 11 | es |
| dc.publication.initialPage | e1800282 | es |
In Vitro Toxicity of Asparagus Saponins in Distinct Multidrug-Resistant Colon Cancer Cells
[PDF]
