Artículo
In Vitro Toxicity of Asparagus Saponins in Distinct Multidrug-Resistant Colon Cancer Cells
Autor/es | Jaramillo Carmona, Sara
Guillén Bejarano, Rafael Jiménez Araujo, Ana José Rodríguez Arcos, Rocío López Martín, Sergio |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2018 |
Fecha de depósito | 2022-03-08 |
Publicado en |
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Resumen | Colorectal cancer is the third most common cancer in the world. Many efforts have focused on finding natural molecules with potential chemo-preventive activity due to their low toxicity compared to synthetic drugs. However, ... Colorectal cancer is the third most common cancer in the world. Many efforts have focused on finding natural molecules with potential chemo-preventive activity due to their low toxicity compared to synthetic drugs. However, comprehensive information on the bioactive fractions and components is still missing. In this study, we developed a method for the quantitative separation and isolation of saponins from asparagus genotypes consisting of an adsorption chromatography and subsequent liquid chromatographic separation on a reversed-phase column. The saponins isolated were tested for their cytotoxic activity against human colon cancer cell lines, which could develop cross-resistance to a wide variety of chemotherapeutic drugs. Our results showed that Huétor-Tájar asparagus saponins (HTSAP), mainly protodioscin and HTSAP-10 have higher cytotoxic activity than HTSAP-1, HTSAP-6, and HTSAP-8. This study links the potential anticancer effect of asparagus to specific saponins and unveils the triguero Huétor-Tájar asparagus as a nutraceutical particularly in colon cancer therapies |
Identificador del proyecto | JCI-2012-13084 |
Cita | Jaramillo Carmona, S., Guillén Bejarano, R., Jiménez Araujo, A.J., Rodríguez Arcos, R. y López Martín, S. (2018). In Vitro Toxicity of Asparagus Saponins in Distinct Multidrug-Resistant Colon Cancer Cells. Chemistry and Biodiversity, 15 (11), e1800282. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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In Vitro Toxicity of Asparagus.pdf | 2.419Mb | [PDF] | Ver/ | |